运动高血压及其生化因子的变化  

EXERCISE HYPERTENSION AND CHANGES OF SOME CIRCULATING FACTORS

作　　者：戴军[1] 毛焕元[1] 周本财[1] 郭和平[1] 梁丛俊 李明慧 陈子星[1] 

机构地区：[1]同济医科大学心血管病研究所,湖北省丹江口市第一医院

出　　处：《中国循环杂志》1995年第4期200-202,共3页Chinese Circulation Journal

摘　　要：对４０例血压正常的原发性高血压患者子女做运动负荷试验表明，１４例出现运动触发性高血压［≥３０／１２．６ｋＰａ（２２５／９５ｍｍＨｇ）］，其肾素活性、血管紧张索Ⅰ（ＡｎｇⅠ）、血浆５－羟吲哚类物质浓度运动后均较正常血压者升高（Ｐ＜０．０５）；内源性洋地黄因子显著升高（Ｐ＜０．００１），而运动后降低；血小板５－羟色胺运动后降低。高血压患者子女运动后心钠素较对照组升高（Ｐ＜０．０５），６－酮－前列腺素Ｆ１α、凝血烷Ｂ２（ＴＸＢ２，血栓素Ｂ２）无差异。The blood pressure(BP) responses to exercise of normotensives, aged 27±3 yrs. at high risk(positive parental history of hypertension,n=40) and at low risk(negative parental history of hypertension, n=20) were studied. All had normal body weight and resting blood pressure. During graded bicycle exercise,35% (14/40) of the high risk subjects bad exaggerated BP response[≥30/12. 6 kpa(225/95 mmHg)] versus 0% of the low risk subjects. The changes of some circulating factors to exercise were also evaluated. The PRA and plasma All concentration in exaggerated BP responders rose to maximum at the end of exercise.The plasma endogenous digitalis-like substance (EDLS) in exaggerated BP responders was already elevated before exercise, and decreased by exercise. Plasma atrial natriuretic peptide(ANP) in the high-risk group increased significantly after exercise vs. the lowrisk group, whereas plasma ANP of the high-risk exaggerated responders was the highest.Plasma 6-keto-PGF1a and thromboxane Ba increased with exercise . but no significant difference was found between the 2 groups. Exaggerated response of plasma 5-HT to exercise in exaggerated BP subjects was marked.The platelet 5-HT concentration in exaggerated BP persons was decreased before exercise.

关 键 词：高血压 运动高血压 血管紧张素A 血清素 

分 类 号：R544.1[医药卫生—心血管疾病]