高胰岛素血症的高血压患者肾素─血管紧张素─醛固酮系统的变化  

CHANGES OF RAAS IN ESSENTIAL HYPERTENSIVE PATIENTS WITH HYPERINSULINEMIA

作　　者：孙宁玲[1] 朱继红[1] 张瑞军 陈穗金 杨宗于[1] 苟淑琴[1] 

机构地区：[1]北京医科大学人民医院心内科,北京医科大学人民医院核医学科,山东齐鲁石化职工医院

出　　处：《中国循环杂志》1995年第10期587-590,共4页Chinese Circulation Journal

摘　　要：本文对３５例原发性高血压患者糖耐量试验前后的血压、血糖、胰岛素、Ｃ肽及肾素－血管紧张素－醛固酮系统（ＲＡＡＳ）进行测定及监测，并与正常人对照。结果显示：高血压病组存在高胰岛素血症及胰岛素抵抗现象，ＲＡＡＳ反应性增高。表明高胰岛素血症的高血压患者其ＲＡＡＳ的变化，在高血压的发病中起着一定作用，由糖负荷诱导的急性血压升高及ＲＡＡＳ的变化，在有胰岛素抵抗的高血压患者要比正常人更为明显。高胰岛素血症患者的ＲＡＡＳ持久性反应增高可能是促进高血压病进展的原因之一。In 35 patients with essential hypertension,blood pressure,plasma glucose,C peptide and PRA,AII,Ald (RAAS)were measured before and after oral glucose tolerance test,and compared to normotensive controls(n=15).The results showed hyperinsulinemia,insulin resistance and increased reaction of the RAAS in the hypertensive group.The acute increases of blood pressure and RAAS,induced by glucose load,were higher in the hypertensives with insulin resistance than in the controls.So,hyperinsulinema with persistant increased reaction of RAAS might be an important factor in the pathogenesis and/or development of hyperrension.

关 键 词：高血压 胰岛素抗性 肾素 血管紧张素 醛固酮 

分 类 号：R544.102[医药卫生—心血管疾病]