正常人口服甘露醇的药动学研究  

A Pharmacokinetic Study on Mannitol Administered Orally in Healthy Volunteers

作　　者：康丕顺[1] 汤关龙[1] 杨肇亨[1] 王海涛[1] 胡常成 

机构地区：[1]第三军医大学附属第三医院,重庆医科大学附属第一医院药剂科

出　　处：《中国药房》1995年第4期25-26,共2页China Pharmacy

摘　　要：口服甘露醇治疗内科疾病报道颇多。但是，包括经典在内的几乎全部文献资料都认为口服不吸收。为了提供治疗学依据，指导临床用药，本文报道对８名健康自愿受试者进行了口服药代动力学研究，血药浓度时间数据采用夏文江氏（ＭＣＰＫＰ）药代动力学程序，计算机自动拟合，所得数据符合开放性二室模型（一级吸收），分布半衰期（ｔ１／２α）为０．６８小时，消除半衰期（ｔ１／２β）为３．６４小时，最高血药浓度（Ｃｍａｘ）为４３１μｇ／ｍｌ，肾清除率（Ｋｅｌ）为０．４９０小时，达峰时间（ＴＰ）为１．０小时。本实验结果提供了药效学依据，所供参数对临床制订给药方案具有重要参考价值：计算结果还显示了个体差异明显，提示了药物剂型或给药途径还值得进一步研究。In recent years there are a lot of reports about treating internal diseases with oral mannitol, but it is generally considered that oral administration of mannitol cannot be absorbed.For providing the therapeutic basis and guiding the clinical use of this drug,pharmacokinetic parameters of mannitol administered orally were determined in 8 healthy volunteers.The data of time-serum concentration were managed in a computer by Xia Wenjiang's pharmacokinetic parameter program (MCPKP).It showed the two compartment open model(first-order kinetics),t1/2α=0.68h,t1/2β=3.64h,Cmax=431μg/ml,AUC=1629ml/L.h,Kel=0.49h,and TP=1.0h.These parameters provided the pharmacokinetic basis and were of great value for making plan of giving medicine.The significant individual difference existing in the study suggested that pharmaceutical dosage-forms and methods of giving medicine should be further studied.

关 键 词：甘露醇 血药浓度 开放性二室模型 药动学参数 

分 类 号：R969.1[医药卫生—药理学]