舒脑胶囊在健康人体内的药动学研究  

Study on the Pharmacokinetics of Shunao Capsule in Healthy Subjects

作　　者：朱春英[1] 陈贵文[1] 董秀兰[1] 王美村[1] 

机构地区：[1]哈尔滨医科大学附属一院药剂科

出　　处：《中国药房》1995年第4期27-28,共2页China Pharmacy

摘　　要：本文建立了高效液相色谱法（ＨＰＬＣ）测定舒脑胶囊人体血药浓度的方法，并测定了１３名健康受试者单剂量口服舒脑胶囊７０ｍｇ的血药浓度，结果表明舒脑胶囊在人体内的药代动力学模型符合单室开放模型，药代动力学参数：达峰浓度是０．３９５８±０．０１１μｇ／ｍｌ．达峰时间为３．２３２±０．０６５ｈ，消除半衰期为２．９１４±０．１３４ｈ，血药浓度曲线下面积ＡＵＣ０￣８３．１１３±０．０６４μｇ／ｍｌ．ｈ。In 13 healthy volunteers,the bloodconcentrations of Shunao were measured by HPLC after a single oral 70mg dose of Shunao capsule.The results showed that the pharamacokinetics of Shunao could be described by a single compartment open model. The pharmacokinetic parameters were as follow: Cmax0.3958±0.011μg/ml,Tmax 3.232±0.065h,tv,2.914±0.134h and AUC0￣83.113±0.064μg/ml·h.

关 键 词：高效液相色谱 舒脑胶囊 药代动力学 

分 类 号：R969.1[医药卫生—药理学]