HPLC法测定压平乐血药浓度及药代动力学研究  

Determination of Serum Concentration of Atenolol by HPLC and Study of the Pharmacokinetics

作　　者：宋永熙[1] 陈贵文[1] 倪燕[1] 朱玉琦[1] 

机构地区：[1]哈尔滨医科大学附属第一医院药剂部,哈尔滨医科大学附属第一医院麻醉科

出　　处：《中国药房》1995年第6期28-29,共2页China Pharmacy

摘　　要：本文采用反相ＨＰＬＣ法测定压平乐健康人血清浓度，并对压平乐片的药动学进行了研究。色谱柱为ＳｐｈｅｒｉｓｏｒｂＣ１８，４．６×１５０ｍｍ，流动相为甲醇－０．０２Ｍ磷酸氢二铵（９：１）。检测波长为２２７ｎｍ，流速０．５ｍｌ／ｍｉｎ。用ＰＫＢＰ－Ｎ１程序拟合血浓－时间曲线，结果符合一室模型，其半衰期为ｔ１／２＝７．２１±０．８９ｈ。The serum concentrations of Atenolol were determined bv RP～HPLC andthe pharmacokinetics of Atenolol was studied with column of spherisorb C18 and a mobile phase of methanol-diammonium hydrogen phosphate(9:1)The detection wave length was 227nm and flow rate 0.5ml/min The results showed that the pharmacokinetics of Atenolol could be described by a single compartment model.The half life time was 7.21±0.89h.

关 键 词：压平乐 HPLC法 药代动力学 

分 类 号：R972[医药卫生—药品]