旱莲草的抗炎作用及机制研究  

Antiinflammatory Effects Of Herba Eclipta Prostrata

作　　者：胡慧娟[1] 周德荣[1] 杭秉茜[1] 马嵬 

机构地区：[1]中国药科大学中药药理学教研室

出　　处：《中国药科大学学报》1995年第4期226-229,共4页Journal of China Pharmaceutical University

摘　　要：旱莲草水煎剂５，１５ｇ／ｋｇ，连续７ｄ灌胃给药，对巴豆油所致小鼠耳廓肿胀，醋酸引起的小鼠腹腔毛细血管通透性增高以及组织胺引起的大鼠皮肤毛细血管通透性增高均有明显的抑制作用；对角叉菜胶，甲醛所致大鼠足垫肿胀也有显著的抑制作用，摘除双侧肾上腺后其抗炎作用仍然存在。旱莲草还能显著抑制大鼠棉球肉芽组织增生，抑制角叉菜胶所致胸腔渗出液中白细胞的数量及炎性组织中ＰＧＥ的含量。Docoction of Herba Elicpta prostrata markedly decreased the swelling of mouse ear induced by Croton oil,and inhibited the increase of capillary permeability caused by acetic acid in mice and by histamine in rats.HEP also inhibited hindpad swelling induced by carragenan and formaldehyde in rats.Similar effects were seen in adrenalectomized rats.HEP supressed the proliferation of granuloma caused by cotton pellets,the content of prostaglandin E2 in inflammatory tissue induced by carrageenan,and the migration of leucocyte.It is suggested that antiinflammatory effects of HEP may involve various ways affecting inflammatory processes and be in dependent on system of pituitary glandadrenal.

关 键 词：旱莲草 中药药理学 抗炎作用 

分 类 号：R282.710.5[医药卫生—中药学]