气相色谱法测定人血浆中阿替洛尔含量  

Determination of Atenolol in Human Plasma by Gas Chromatography

作　　者：彭建和[1] 涂家生[1] 邢久东[1] 

机构地区：[1]中国药科大学分析计算中心药剂学教研室,中国药科大学分析计算中心药物分析学教研室

出　　处：《中国药科大学学报》1995年第6期344-346,共3页Journal of China Pharmaceutical University

摘　　要：建立了人血浆中阿替洛尔气相色谱测定方法。提取样品经三氟乙酰化，电子捕获检测器检测，最低检测浓度可达５ｎｇ／ｍｌ。方法回收率大于９３％，日内、日间ＲＳＤ分别为２．５％和４．５％，血药浓度在５０～２００ｎｇ／ｍｌ呈线性关系，ｒ＝０．９９８３６，ｎ＝７。The method for determination of atenolol in human plasma by gas chromatography was established. After being extracted from plasma,atenolol is trifluoracetated,and determined by gas chromatography using electron-capture detector(ECD). The lowest determinable concentration,recovery,precision within-day and between days were 5ng/ml,93%, 2.5%and 4.5% respectively.There is a good linear relationship in the plasma concentration ranging from 50 to 200 ng/ml.

关 键 词：阿替洛尔 血药浓度 气相色谱法 药物代谢动力学 

分 类 号：R972[医药卫生—药品] R969.1[医药卫生—药学]