环戊腺苷对异丙肾上腺素诱发的豚鼠乳头状肌后除极和触发活动的影响(英文)  

Effects of N6-cyclopentyladenosine on af terdepolarizations and triggered activity induced by isoproterenol in guinea pig papillary muscle

作　　者：李玉龙[1] 何瑞荣[1] 

机构地区：[1]河北医学院基础医学研究所生理室

出　　处：《中国药理学报》1995年第2期163-168,共6页Acta Pharmacologica Sinica

基　　金：Project supported by the Natural Science Foundation of Hebei Province, №393125.

摘　　要：目的:观察选择性A_1受体激动剂环戊腺苷(CPA)对异丙肾上腺素(Iso)诱发的豚鼠乳头状肌后除极和触发活动的影响.方法:应用Iso 50 nmoi·L^(-1)诱发稳定而可重复的早发和迟发后除极(EAD和DAD).用玻璃微电极技术记录EAD和DAD诸参数.结果:CPA能明显地缓解Iso诱发的豚鼠乳状肌早发后除极、迟发后除极和触发活动.8-苯茶碱和格列苯脲能拮抗CPA对Iso诱发早发和迟发后除极的抑制作用.结论:ATP敏感性钾通道参与了Iso诱发的早发和迟发后除极以及CPA对Iso诱发的两种后除极的抑制作用.AIM:To investigate the effects of N6-cyclopentyladenosine (CPA, selective adeno-sine A1 receptor agonist) on afterdepolar-izations and triggered activity induced by iso-proterenol (Iso) in guinea pig papillary muscle. METHODS: The stable and reproducible early afterdepolarization (EAD) and delayed afterdepolarizaiton (DAD) of guinea pig papillary muslce were induced by Iso 50 nmol.L-1. The parameters of EAD and DAD were recorded using intracellular microelec-trodes. RESULTS: CPA markedly attenuated the development of EAD, DAD, and triggered activity (TA) induced by Iso in guinea pig papillary muscle. The inhibitory effects of CPA on Iso-induced EAD and DAD were antagonized by 8-phenyltheophylline ( 8-PT) and glibenclamide (Gli ). CONCLUSION: ATP-sensitive K+ channels were involved in Iso-induced EAD and DAD, and in the inhibitory effects of CPA on EAD and DAD.

关 键 词：腺苷 异丙肾上腺素 茶碱 格列苯脲 乳头状肌 

分 类 号：R965.2[医药卫生—药理学]