组氨酸改善大鼠血栓形成性局部脑缺血时脑水肿及心功能障碍(英文)  

Histidine ameliorated brain edema and cardiac dysfunction during local thrombotic cerebral ischemia in rats

作　　者：李树清[1] 韩红[1] 何洁[1] 

机构地区：[1]昆明医学院病理生理教研室

出　　处：《中国药理学报》1995年第2期156-159,共4页Acta Pharmacologica Sinica

基　　金：Project supported by the Science Foundation of the Ministry of Public Health of China, №941358.

摘　　要：目的:观察组氨酸对脑血栓形成后脑水肿及心 功能障碍的影响.方法:用光化学法诱导大鼠血栓形成性局部脑缺血.结果:大鼠脑血栓形成后脑水份明显增加(P<0.01),左室收缩压(LVSP)峰值及左室内压变化速率(dp/dt_(max))明显降低(P<0.05).结论:iv组氨酸5 mg·kg^(-1)可明显改善脑缺血所致脑水肿及心功能障碍而具有保护脑功能效应.AIM: To observe the effects of histidine (iv 5 mg . kg-1) on brain edema and cardiac disturbance after cerebral thrombosis. METHODS: Regional cerebral thrombosis was induced by photochemical method in rats. RESULTS: It was showed that the brain water content increased markedly (85. 6 ±3.8%, .P<0. 01); the left ventricular systolic pressure (LVSP, 17. 9±1. 5 kPa) and the maximal left ventricular contractility decreased (+dp/dtmax 645±110 kPa and -dp/dtmax 473±106 kPa, P<0. 05). In rats treated with histidine after photochemical reaction, the brain water content decreased (81. 5±2.0 %) while LVSP (21. 2±1.1 kPa) and left ventricular ±dp/dtmax and -dp/dtmax increased markedly (777±144 kPa and 604 ±157 kPa, respectively). CONCLUSION: Histidine has protective effects on the brain and cardiac function during cerebral thrombosis.

关 键 词：光化学 血栓形成 脑缺血 脑水肿 组氨酸 

分 类 号：R965.2[医药卫生—药理学]