丙戊酸恒速给药在小鼠体内时间药物动力学及进食条件的影响(英文)  

Cbronopharmacokinetics of valproic acid following constant-rate administration in mice and influence of feeding schedule

作　　者：宋建国[1] 大户茂弘 小川暢也 

机构地区：[1]爱嫒大学医学部药理学教研室

出　　处：《中国药理学报》1995年第2期113-117,共5页Acta Pharmacologica Sinica

摘　　要：目的:研究丙戊酸(VA)药物动力学昼夜节律变化及进食条件对节律的影响.方法:对自由进食及限定进食的ICR小鼠分别以渗透压微泵技术(1.062 mg·h^(-1))及iv(50 mg·kg^(-1))给予丙戊酸钠,并测定VA动力学的时间依赖性变化.结果:血浆VA浓度及清除率在稳态时呈昼夜节律性变化(P<0.01),限定进食时间影响VA动力学的节律,使峰值位相移动约12h.结论:用药时间是影响VA药动学的重要因素.进食条件是VA药动学节律的同步因子之一.AIM:To study the circadian rhythm in phar-macokinetics of valproic acid(VA) and influence of feeding schedule on the rhythm. METHODS: Sodium valproate was administered by osmotic minipump technique (1. 062 mg·h-1) and iv (50 mg·kg-1) to ICR mice fed under ad lib or time-restricted schedules to determine the time-dependent changes of VA kinetics. RESULTS: Plasma VA concentration and clearance at steady-state showed circadian rhythms (P<0. 01). Time-restricted feeding influenced the rhythm of VA kinetics, acrophases of rhythms shifted approximately 12 h. CONCLUSION: Timing of dosing is important for VA kinetics and feeding schedule is one of synchronizers in VA kinetics.

关 键 词：丙戊酸 昼夜节律 用药计划表 药代动力学 小鼠 

分 类 号：R965.2[医药卫生—药理学]