石杉碱甲片对阿耳茨海默病记忆、认知和行为的疗效(英文)  

Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease

作　　者：徐嗣荪[1] 高之旭[2] 翁正[3] 杜尊铭 徐维安 杨健身 张明廉[7] 童振华[1] 方雍生[2] 柴新生[3] 李淑兰[4] 

机构地区：[1]浙江医科大学浙江省药物滥用监测站,杭州310009 [2]上海市精神卫生中心,上海200030 [3]山东省精神卫生中心,济南250014 [4]杭州铁路中心医院,杭州310009 [5]上海市第三精神病院,上海201905 [6]苏州普济医院,苏州215008 [7]苏州广济医院

出　　处：《中国药理学报》1995年第5期391-395,共5页Acta Pharmacologica Sinica

摘　　要：目的：评估石杉碱甲片治疗阿耳茨海默病的疗效及其安全性.方法:采用多中心、前瞻性、双盲、平行、空白对照和随机方法,给50例阿尔采末病一日两次口服石杉碱甲片4片(每片含50微克),并给53例阿耳茨海默病一日两次口服安慰剂片4片,共8wk.所有病人都用韦氏智力量表、简易精神状态量表、长谷川痴呆量表、日常生活能力量表、副反应量表和其他实验室检查.结果:发现58％(29/50)的石杉碱甲片服用者改善了所有的记忆、认知和行为能力,而安慰剂组仅为35.8％(19/53),两组疗效有显著差异(X^2=5.07,P<0.05),而两组均无严重不良反应发生.结论:石杉碱甲片显著增高记忆、认知和行为功能,是治疗阿耳茨海默病的一个有前景的药物.AIM:To evaluate the efficacy and safety of tablet huperzine-A (Hup) in patients with Alzheimer's disease. METHODS: Using mul-ticenter, prospective, double-blind, parallel, placebo controlled and randomized method, 50 patients were administrated orally 0. 2 mg (4 tablets) Hup and 53 patients were given po 4 tablets of placebo bid for 8 wk. All patients were evaluated with Wechsler memory scale, Hasegawa dementia scale, mini-mental state examination scale, activity of daily living scale, treatment emergency symptom scale, and measured with BP, HR, ECG, EEG, ALT, AKP, BUN, Cr, Hb, WBC, and urine routine. RESULTS: About 58 % (29/50) of patients treated with Hup showed improvements in their memory (P <0. 01), cognitive (P<0. 01), and behavioral (P<0. 01 functions. The efficacy of Hup was better than placebo (36 %, 19/53)(P<0. 05). No severe side effect was found. CONCLUSION: Hup is a promising drug for symptomatic treatment of Alzheimer's disease.

关 键 词：石杉碱甲 阿耳茨海默病 双盲法 记忆 认知障碍 

分 类 号：R971.4[医药卫生—药品]