绞股蓝总皂甙在沙门菌试验中的抗诱变作用  

Antimutagenic effects of Gypenosides(GP)in salmonella test

作　　者：王迎进[1] 白元让[1] 

机构地区：[1]西安医科大学药理教研室

出　　处：《中国药理学通报》1995年第1期43-45,共3页Chinese Pharmacological Bulletin

摘　　要：以阿地平（ＡＢ），柔红霉素（ＤＮ）．迭氨化钠（ＳＡ），丝裂霉素Ｃ（ＭＭＣ）分别作为沙门诱变菌株ＴＡ９７、ＴＡ９８、ＴＡ１００、ＴＡ１０２的诱变因子．以回变菌落数下降为指标。观察绞股蓝总皂甙（ＧＰ）的抗诱变作用。实验结果显示ＧＰ能拮抗以上４种诱变因子的诱变作用，并有剂量─效应关系。Aset of histidine-requiring strains TA97.TA98.TA100,TA102was used for antimutagenicity test.4 mutagenic agents such as Atabrine(AB).Daunorubicin (DN).Sodium Axide(SA).Mitomycin C(MMC) were used to make mutagenic model and antimutagenic effects of GP was observed,Every tester strain was divided intocontrol group·model group and GPgroups.AB.DN.SA and MMC were mutagenic agents for TA97,TA98,TA100and TA102respectively.The results showed that GPinhibited mutagenic effects induced by 4 model agents. The inhibitory rates were56.0% ,74.7% .94.5% for AB; 23.1% , 40.2% , 57.9% for DN; 34.0% , 59.3%, 94.5% for SA and 22.0% . 50. 5% . 64. 3% for MMC respectivelThese data suggestthat GP has the effects of inhibiting mutagenesis induced by AB.DN, SA, MMC insalmonella test with dose-dependent manner and is very likely to have a protective action on the carcinogens.

关 键 词：绞股蓝 总皂甙 沙门诱变菌株 诱变因子 抗诱变 

分 类 号：R285.5[医药卫生—中药学]