西洋参茎叶皂甙单体Rb_3对大鼠血流动力学及单钙通道活动的影响  

Influence of panax quinquefolium saponin monomer Rb_3 on hemodynamics and single calcium channel activity in rats

作　　者：杨世杰[1] 陈霞[1] 李红[1] 钟国赣[1] 张文杰[1] 孙成文[1] 王晓明[1] 江岩[1] 

机构地区：[1]白求恩医科大学药理教研室,白求恩医科大学生理教研室,白求恩医科大学生理中心实验室

出　　处：《中国药理学通报》1995年第1期39-43,共5页Chinese Pharmacological Bulletin

摘　　要：单体皂甙Ｒｂ３自西洋参茎叶皂甙中提取。Ｒｂ３３０ｍｇ·ｋｇ－１可使麻醉大鼠在体心脏的ＭＡＰ，±ｄＰ／ｄｔｍａｘ和ＬＶＳＰ减少。用斑片钳的连细胞电压钳法证明．Ｒｂ３３００ｍｇ·Ｌ－１使Ｌ、Ｂ、Ｔ型钙通道的开放时间缩短、开放概率减少，其作用与异搏定３７．５ｍｇ·Ｌ－１相似，与ＢａｙＫ８６１１５μｍｏｌ·Ｌ－１作用相反。确切地证明Ｒｂ３对钙通道有阻滞作用。Saponin monomer Rb3 was extracted from the stems and leaves of Panaxquinquefolium.Rb3 30 mg· kg-1 decreased the MAP.±dP/dtmax and LVSP of anaesthetic rat hearts in vivo. Using the cell attached configration of the patch clamp technique,it was demonstrated that Rb3 300 mg· L-1 decreased the open time and the open-state probabillity of L. Band T type calcium channels. The effect was similar to that of verapamil 37.5 mg·L-1 and opposite to that of Bay K8644 5 μmol· L-1. Theresults conclusively prove that Rb3 has blockade effect on calcium chanls.

关 键 词：西洋参 皂甙 钙通道 血流动力学 

分 类 号：R285.5[医药卫生—中药学]