8，14－二氢萨鲁塔里啶碱和青藤碱对大鼠离体心脏功能的影响  

Effects of 8,14-dihydrosalutalidine and sinomenine on cardiac function in isolated working rat hearts

作　　者：金其泉[1] 韦颖梅[1] 

机构地区：[1]蚌埠医学院药理教研室

出　　处：《中国药理学通报》1995年第2期139-142,共4页Chinese Pharmacological Bulletin

摘　　要：８，１４－二氢萨鲁塔里啶碱（ＤＨＳ）和青藤碱（ＳＩＮ）均系从青风藤根茎中提取的生物碱，已知青藤碱在抗心律失常方面有一定作用。实验观察ＤＨＳ和ＳＩＮ对高体大鼠工作心脏心功能的影响发现：８２μｍｏｌ·Ｌ－１ＳＩＮ灌注正常高体大鼠工作心脏６０ｍｉｎ后，ＭＡＰ、ＬＶＳＰ、＋ｄＰ／ｄｔｍａｘ明显下降，ＬＶＥＤＰ、Ｔ值显著升高，说明ＳＩＮ对大鼠工作心脏有抑制作用。８２μｍｏｌ·Ｌ－１ＤＨＳ灌注后对心脏的收缩功能有一定抑制作用，但对舒张功能影响较小。提示ＤＨＳ在保护心功能方面有一定的作用。dihydrosalutalidine (DHS) and sinomenine (SIN) were extracted from the root of slnomenium acuturm Rend et voils.SIN possesses the antiarrhythmic effect.Effects of DHS and SIN were estimated in isolated working rat hearts.The experimented results are as follows:After perfusion of SIN 82μmol·L￣(-1)for 50 min.MAP,LVSP and+dP/dt_(max)markedly reduced,but LVEDP and T value augmented.Results show that SIN has the inhibitory effect on cardiac function.DHS 82μmol·L￣(-1) also has the inhibitory effect on the myocardial contractility function,but not that on the myocardial diastolic function.

关 键 词：生物碱 DHS 青藤碱 心脏功能 

分 类 号：R285.5[医药卫生—中药学]