磷脂酶A_2抑制剂及抗氧化剂对内毒素所致生物膜损伤的保护作用  

The protective effects of phospholipids A_2 inhibitors and antioxidant on biomembrane injuries induced by endotoxin administration in rats

作　　者：吕礼应[1] 康格非[1] 

机构地区：[1]安徽医科大学附属医院检验科,重庆医科大学临床生化教研室

出　　处：《中国药理学通报》1995年第2期160-163,共4页Chinese Pharmacological Bulletin

摘　　要：研究磷脂酶Ａ２抑制剂及抗氧化剂对内毒素所致红细胞膜损伤的保护作用。结果表明：磷脂酶Ａ２抑制剂氯丙嗪及地塞米松能明显改善内毒素所致的红细胞膜磷脂降解及脂质过氧化反应的增强，抗氧化剂维生素Ｅ则具有显著的抗氧化能力。提示：由磷脂酶Ａ２激活所介导的膜磷脂降解及脂质过氧化在内毒素所致生物膜损伤中具有重要意义。The protective effects of phospholipase A2 inhibitors, chloropro mazine and dexamethasone, and antioxidant vitamine E on biomembrane injuries induced by endotoxin administration were studied in Wistar male rats.The results showed that phospholipase A2 inhibitors could significantly prevent the membrane phospholipids structure from phospholipase A2 induced degredation and reduce the accumulation of lipid peroxide induced by endotoxin administration, and antioxidant vitamine E had a powerful ability of antioxidation.The data mentioned above suggest that the activation of phospholipase A2 and lipid peroxidation plays a critical role in the process of biomembrane injuries induced by endotoxin administration.(Department of Clinical Biochemistry,Chongqing MedicalUniversity,Chongqing 630041)

关 键 词：磷脂酶A2 脂质过氧化 内毒素 生物膜损伤 

分 类 号：R977.3[医药卫生—药品]