人参二醇组皂甙预治疗内毒素休克鼠血清LPO、SOD的变化  

Change of lipid peroxidase and superoxide dismutase in serum of the endotoxic shock rats was prevented by the panaxadiol saponin

作　　者：刘媛媛[1] 吕美德[1] 赵学俭[1] 赵丹[1] 

机构地区：[1]白求恩医科大学第一附属医院传染科,白求恩医科大学第一附属医院病生教研室

出　　处：《中国药理学通报》1995年第2期163-165,共3页Chinese Pharmacological Bulletin

摘　　要：将粗制大肠杆菌内毒素注入大鼠腹腔复制休克模型，将１２８只Ｗｉｓｔａｒ大鼠随机分成内毒素休克组（ＥＳＧ），内毒素休克·人参二醇组皂甙预治疗组（ＥＳＰＧ），对照组（ＣＧ）。结果发现：ＥＳＰＧ组大鼠８ｈ、１６ｈ血清过氧化脂质含量低于ＥＳＧ组，两组差异显著（Ｐ＜０．０５）；血清超氧化物歧化酶活力与血清过氧化脂质含量呈明显负相关（ｒ＝－０．８０６，Ｐ＜０．０１）。提示人参二醇组皂甙是通过提高超氧化物歧化酶活力，减少过氧化脂质产生来达到稳定细胞膜、治疗休克作用的。Experimental models were duplicated by injection of semifinished coliendotoxic into the abdominal cavity in rats.128 wistar rats were randomly divided into 3 groups:endotoxic shock (ESG), panaxadiol saponin pretreated group (ESPG), and control group (CG).It was found that serum lipid peroxidase level of the ESPG was significantly lower than that of the ESG at 8 and 16 h after injection (P<0.05);Serum superoxide dismutase level of the ESPG was significantly higher than that of the ESG (p<0. 05). In addition serum SOD activity and serum lipid peroxidase were negatively correlated in the ESPG (r=-0.806, P<0.01). It indicates that panaxadiol saponin has a protective effect against endotoxic shock in rats though increasing the activity of SOD and decreasing the level of the lipidperoxide.

关 键 词：内毒素 休克 人参 过氧化脂质 超氧化物歧化酶 

分 类 号：R285.5[医药卫生—中药学] R269.314[医药卫生—中医学]