白芍总甙、芍药甙和白芍总甙去除芍药甙对佐剂性关节炎大鼠的免疫调节作用  

Immunoregulatory effects of total glucosides of paeony (TGP),paeoniflorin (PF) and TGP removed PF on adjuvant arthritic rats

作　　者：葛志东[1] 周爱武[1] 王斌[1] 沈玉先[1] 丁长海[1] 张安平[1] 魏伟[1] 徐叔云[1] 

机构地区：[1]安徽医科大学临床药理研究所

出　　处：《中国药理学通报》1995年第4期303-305,共3页Chinese Pharmacological Bulletin

摘　　要：福氏完全佐剂致炎后ｄ１８，佐剂性关节炎（ＡＡ）大鼠刀豆素Ａ（３ｍｇ·Ｌ－１）诱导的脾淋巴细胞增殖反应显著低于正常对照水平，脂多糖（６ｍｇ·Ｌ－１）诱导的大鼠腹腔巨噬细胞（ＰＭΦｓ）产生ＩＬ－１显著高于正常对照大鼠。０．５～３１２．５ｍｇ·Ｌ－１白芍总甙（ＴＧＰ）、芍药甙（ＰＦ）和白芍总甙去除芍药甙（ＴＧＰ－ＰＦ）均能浓度依赖性地增强ＡＡ大鼠低下的脾淋巴细胞增殖反应（量效曲线均呈钟罩形），降低ＡＡ大鼠ＰＭΦｓ过度产生ＩＬ－１（量效曲线均呈倒钟罩形）。其中，２．５～６２．５ｍｇ·Ｌ－１ＴＧＰ的调节作用显著强于ＰＦ和ＴＧＰ－ＰＦ各等剂量组。这些结果表明，上述三种药物均具有浓度和机能依赖性的双向免疫调节作用，ＴＧＰ的作用最强。On dsy 18 post Freunds complete adjuvant injection,concanavalin A (Con A) -induced splenic lymphocyte proliferation in rats was suppressed markedly,and peritoneal macrophages (PMΦs) from arthritic rats induced by lipopolysaccharide (LPS) produced interleukin 1 (IL-1) much more that of the control group.TGP, PF and TGP removed PF (TGP-PF) (0.5～312.5 mg·L-1) possessed the promoting effect on the splenic lymphocyte proliferation and the inhibitory effect on the IL-1production. Their concentration-effect curves were bll-shaped in Con A-induced splenic lymphocyte proliferation and upsidedown bell-shaped in LPS-induced IL-1 production.The immunoregulatory actions of TGP (2.5～62. 5 mg·L-1) on adjuvant arthritic rats were potenter than that of the same concentration of either TGP or TGPPF.The results suggested that all TGP,PF and TGP-PF possess a dual immunomodulatory effect on the splenic lymphocyte proliferation and IL-1 production by PMΦs from adjuvant arthritic rats, depending upon their concentration and the functional state of animals,in which TGP is the potentest.

关 键 词：白芍总甙 芍药甙 关节炎 免疫调节 TGP-PF 

分 类 号：R979.5[医药卫生—药品]