含5－FU的杂氮硅三环衍生物抗瘤活性及吞噬活性的测定  

Antitumor activity and phagocytic function of silatrane derivatives containing 5-FU

作　　者：叶发青[1] 师家福[1] 

机构地区：[1]湖北咸宁医学院医用化学教研室,湖北咸宁医学院医用药理教研室

出　　处：《中国药理学通报》1995年第5期389-391,共3页Chinese Pharmacological Bulletin

摘　　要：观察含５－ＦＵ的杂氮硅三环衍生物Ⅴ对小鼠肉瘤Ｓ－１８０及ＥＳＣ的抑瘤活性及其对荷瘤小鼠吞噬功能的影响。结果表明：化合物Ⅴ对小鼠Ｓ－１８０，ＥＳＣ抑瘤率分别可达６７．１％，５６．７％，并能增强荷瘤小鼠腹腔吞噬细胞的吞噬功能，其吞噬百分率与吞噬指数与对照组相比差异均有显著意义。The paper studied the antitumor activity and phagocytic function of silatrane V derivatives containing 5-FU. The results showed that V possessed significant antitumor activity to S-180, ESC. The inhibition rate of tumor growth were 67.1% for S-180 and 56.7% for ESC.The phagocytic function test indicated that the phagocytic function of peritoneal macrop hages was obviously promoted by administration of silatrane V derivatives containing 5-FU.

关 键 词：杂氮硅三环 5-氟尿嘧啶 抗肿瘤作用 吞噬细胞 

分 类 号：R979.19[医药卫生—药品]