内源性组胺经突触前组胺H_3受体介导抑制心交感神经冲动传递  

Endogenous histamine inhibits cardiac sympatheic neurotrans-mission by interacting with presynaptic histamine H_3-receptors

作　　者：罗晓星[1] 谭月华[1] 

机构地区：[1]第四军医大学药理学教研室

出　　处：《中国药理学与毒理学杂志》1995年第1期47-49,共3页Chinese Journal of Pharmacology and Toxicology

摘　　要：采用豚鼠离体右心房标本观察内源性组胺对心交感神经冲动传递的影响。以组氨酸１ｕｍｏｌ·Ｌ￣（－１）温育右心房标本以增加心肌组胺的合成，１ｈ后施以电场刺激。心房肌正性变力效应较正常降低２６％。雷尼替丁（１ｕｍｏｌ·Ｌ￣（－１））和氯苯吡胺（１ｐｍｏｌ·Ｌ￣（－１））对上述抑制效应无影响。Ｈ＿３受体拮抗剂布立马胺可浓度依赖性地拮抗上述效应。Ｈ＿３受体激动剂（Ｒ）－ａ－甲基组胺则可抑制布立马胺的作用用肥大细胞脱颗粒剂化合物４８－８０温育标本１５ｍｈ。可使电场刺激诱发的正性变力效应增强７５％。结果提示。内源性组胺可能通过交感神经末梢突触前膜组胺Ｈ＿３受体，参予去甲肾上腺素释放的负调节。The isolated atria of guinea pig were incubated with histidine (1umol·L￣(-1)) to increase thesynthesis of endogenous histamine and series of wash-ing steps were performed to eliminate excess histidine.The positive inotropism induced by field stimulationwas depressed bv 26% of control value after treatmentwith histidine. The inhibitory effect was antagonisedby burimamide concentration dependently, but not byranitidine(1 umol·L￣(-1))and chlorpheniramine(1umol·L￣(-1)).The effect of burimamide was inhibited by(R)-a-methylhistamine After exposure to mast celldegranulator, compound 48-80,the positive inotropiceffect evoked by field stimulation was increased by75%。Theresults suggested that inhibition of carkiac sympathetic eurotransmission by endogenoushistamine might be mediated by histamineH_3-receptors.

关 键 词：受体 组胺 甲基组胺类 药理作用 

分 类 号：R962[医药卫生—药理学]