低浓度非洛地平对豚鼠右心室乳头肌动作电位的影响  

Effect of low concentration felodipine on actionpotential of papillary muscle in guinea Pigs 1

作　　者：郑平[1] 史念慈[1] 杨藻宸[1] 

机构地区：[1]上海医科大学基础医学院药理学教研室

出　　处：《中国药理学与毒理学杂志》1995年第3期189-191,共3页Chinese Journal of Pharmacology and Toxicology

摘　　要：用细胞内微电板方法研究低浓度非洛地平对豚鼠右心室乳头肌动作电位的作用。非洛地平０．１，１ｎｍｏｌ·Ｌ－１对动作电位无作用。但在５ｎｍｏｌ·Ｌ－１时，非洛地平可明显延长动作电位时程。延长作用的起效时间为５ｍｉｎ，作用持续６０ｍｉｎ以上。用台氏液冲洗可使非洛地平的延长作用消失。非洛地平５ｎｍｏｌ·Ｌ－１和３μｍｏｌ·Ｌ－１对动作电位时程具有低浓度延长，高浓度缩短的双相作用。硝苯地平１ｎｍｏｌ·Ｌ－１可明显延长动作电位时程，但维拉帕米０．１．１和５ｎｍｏｌ·Ｌ－１对动作电位无明显作用。这表明低浓度激动心肌钙通遁可能是二氢吮嚏矣钙拮抗剂的共性，但不是所有钙拮抗剂的共性。Effect of low concentration felodipine (Fel)on action potential of papillary musclc in gulnea pig was stu-died by microelectrode technique. At 0.1 and 1 nmol· L-1Fel had no effect on the action potentials, but at 5 nmol·L-1, it caused a significant prolongation of the action poten-tials. This effect occurred at 5 min, persisted in the contin-ued presenee of Fel and was reversible after washing out thedrug. In the same preparation, Fel at 3 μmol· L-1.markedly shortened these parameters. Nifedipine at 1nmol· L-1 had similar effects to Fel at low concentration.but verapamil at similar concentrations had no such effects.This suggested that myocardial calcium channel activationat very low coneentration might be a general property ofdihydropyridines, but was not a general property of all calci-uni channel blockers.

关 键 词：非洛地平 心室 乳头乳 动作电位 豚鼠 

分 类 号：R972[医药卫生—药品]