促甲状腺素释放激素和氨力农伍用对失血性休克家兔心肌收缩性能的影响  

Effect of thyrotropin-releasing hormone in combination with amrinone on cardiac systolic function in hemorrhagic-shock rabbits

作　　者：周学武[1] 胡德耀[1] 刘良明[1] 吴炎 

机构地区：[1]第三军医大学野战外科研究所

出　　处：《中国药理学与毒理学杂志》1995年第4期307-308,共2页Chinese Journal of Pharmacology and Toxicology

摘　　要：促甲状腺素释放激素和氨力农伍用对失血性休克家兔心肌收缩性能的影响周学武，胡德耀，刘良明，吴炎（第三军医大学野战外科研究所，重庆６３００４２）促甲状腺素释放激素（ｔｈｙｒｏｔｒｏｐｉｎ－ｒｅｌｅａｓｉｎｇｈｏｒｍｏｎｅ，ＴＲＨ）抗休克作用时间短暂［１］...Thyrotropin-releasing hormone(TRH)and amrinone(Amr)combined therapy couldrapidly and significantly increase mean arterial pressure(MAP),left ventricular systolic pressure(LVSP)and isovolumic ventricular pressure(IVP),improve the maximal rate of left ventricular pres-sure changes( ±dp /dtmax),accelerate the maximalphysiological velocity(Vpm)and velocity of thecontractile element shortening at 5.3 kPa of leftventricular pressure(Vce 40),and raise the area ofp-dp/dtmax vector loop(Lo)in the rabbits sub-jected to hemorrhagic shock The main parametersin TRH and Amr combined therapy group were su-perior to Amr group at the early period and to TRHgroup after administration.Morever,the combinedtherapy could increase the arterial bloodpH(P<0.01)and decrease the plasma β-glucuroni-dase activity significantly. TRH in combinationwith Amr could remarkably increase the 24 h surviv-al rate during endotoxic shock in mice as comparedwith normal saline group(P< 0.01).It was sug-gested that the combined therapy had more advan-tages than that of TRH or Amr alone in the treat-ment of shock.

关 键 词：促甲状腺素 释放激素 氨力农 休克 心肌收缩 

分 类 号：R977.1[医药卫生—药品]