香烟依赖与血浆LPO含量及红细胞SOD活性关系的研究  

STUDIES ON THE RELATIONSHIPS BETWEEN SMOKING ANDPLASMA LIPOPEROXIDE CONTENT, ERYTHROCYTESUPEROXIDE DISMUTASE ACTIVITY

作　　者：周君富[1] 丁德云[1] 郭芳珍[1] 钱志君[1] 

机构地区：[1]浙江省药物滥用监测站,浙江医科大学附属第二医院医院感染管理科,浙江医科大学附属第二医院检验科

出　　处：《中国药物依赖性通报》1995年第3期165-169,共5页

摘　　要：检测经配对设计的５７例吸烟者和５７例健康非吸烟者的血浆过氧化脂质（Ｐ－ＬＰＯ）含量以及红细胞超氧化物歧化酶活性（Ｅ－ＳＯＤＡ）的结果表明，与健康非吸烟组比较．吸烟组的Ｐ－ＬＰＯ平均含量显著升高（Ｐ＜０．００１）、Ｅ—ＳＯＤＡ平均值显著降低（Ｐ＜０．００１），吸烟者的Ｐ－ＬＰＯ含量随吸烟者吸烟史和吸烟量的增加而升高、Ｅ－ＳＯＤＡ值随吸烟者吸烟史和吸烟量的增加而降低，并均呈线性相关（Ｐ＜０．００１）；提示吸烟者体内的氧自由基反应及脂质过氧化反应明显加剧。The plasma lipoperoxides( P-LPO) and erythrocyte superoxide dismutase activity (E - SODA) values of 57 smokers and 57 healthy nonsmokers weremeasured. The results showed that the average P - LPO content of the smoker groupwas significantly higher than that of the healthy nonsmoker group(P < 0. 001 ), whilethe average E - SODA value of the smoker group was significantly lower than that ofthe healthy nonsmoker group(P < 0. 001 ), smokers' P - LPO content increased as thesmokers' smoking period and smoking quantity Increased (P < 0. 001), smokers' E -SODA value decreased as the smokers' smoking period and smoking quantity increased(P < 0. 001 ). It suggested that the oxygen free radical reaction and lipoperoxidationreaction in the body of the smokers appeared pathologically aggravated.

关 键 词：吸烟 过氧化脂质 超氧化物歧化酶 

分 类 号：R163[医药卫生—公共卫生与预防医学]