普鲁托品的抗实验性心律失常作用  

Effects of protopine on experimental arrhythmia

作　　者：陆泽安[1] 王德成[1] 陈植和[1] 王新华[1] 

机构地区：[1]昆明医学院药理学教研室,湖南湘潭市第二医院

出　　处：《中国药学杂志》1995年第2期81-84,共4页Chinese Pharmaceutical Journal

摘　　要：采用８种动物实验性心律失常模型观察了普鲁托品（ｐｒｏｔｏｐｉｎｅ）的抗心律失常作用。结果表明，普导托品对由乌头碱、氯化钙、苯－肾上腺素引起的大鼠心律失常、氯仿所致的小鼠心室纤颤、电刺激所致的家兔心室纤颤均有保护作用。其作用机制似主要与其阻滞心肌细胞Ｎａ￣＋通道，延长有效不应期有关。Protopine is an isoquinol ine alkaloid isolated from Dactglicapnos scandens Hutch. We studied its antiarrhythmic effects on experimental arrhythmia, It could elevate the dose ofaconitine to induce VP,VT and VF in rats and increase the dose of strophanthine K to induce VPin guinea pigs,It also shortened the duration of central arrhythmia induced by aconitine in ratsand the duration of arrhythmia induced by benzene-adrenaline in rats. It prevented rats and micefrom arrhythmia induced by iv CaCl_2 rapidly and inhalation of chloroform,respectively. In anaes-thetized rabbits,the drug raised the VFT after administration. In conclusion,protopine hasantiarrhythmic effects on various animal models and the study suggested that it may havedirective inhibitions on rapid electrical activity of the cardiac cells.

关 键 词：普鲁托品 心律失常 抗心律失常药 生物碱 

分 类 号：R285.5[医药卫生—中药学] R972.2[医药卫生—中医学]