诺氟沙星联合用药体系的目标因子分析  

Simultaneous determination of proloxacin,metronidazole and vitamin Cin a compatability system by using target factor analysis-UV spectropho- tometry

作　　者：陈玮[1] 潘忠孝[1] 孙少颖[1] 张懋森[1] 李培芳[1] 屈健[1] 

机构地区：[1]中国科学技术大学化学物理系,安徽省立医院临床药学研究室

出　　处：《中国药学杂志》1995年第5期284-285,共2页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金

摘　　要：利用目标因子分析（ＴＦＡ）－紫外可见分光光度法对新药诺氟沙星针剂与甲硝哇、维生素Ｃ的配伍静滴体系进行了定量分析。所含组分的回收率为９０．６％～１０７．７％。这一结果表明，配伍后各组分的紫外吸收光谱具有良好的加和性。还讨论了波长范围、波长间隔对测定结果的影响，并同人工神经网络法所得结果作了比较，结果计算值基本相同。The UV-spectra data of some compatability systems consisting of proloxacin injec-tion,metronidazole injection and vitamin C injection were measured.The concentrations of thecomponents in the systems were also determined by using target factor analysis successfully.Theresults showed that medicines may keep independent each other in the compatability systems andthat they may also keep their own pharmacological properties in the systems, Effects of wave-length range and the selected sampling interval on the calculated results were discussed,and theresults were compared with those obtained by artificial neural network.

关 键 词：目标因子分析 分光光度法 诺氟沙星 甲硝唑 

分 类 号：R978.1[医药卫生—药品]