苯丙素甙化合物的抗肿瘤活性  

Antitumour effects of phenylpropanoid glycosides

作　　者：李忌[1] 郑耘[1] 郑荣梁[1] 刘自民[1] 贾忠健[1] 

机构地区：[1]厦门大学抗癌研究中心,兰州大学生物系,兰州大学有机化学研究所

出　　处：《中国药学杂志》1995年第5期269-271,共3页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金及福建省自然科学基金

摘　　要：采用抗癌药筛选新方法－ＭＴＴ法，研究了６种从中草药马先蒿（Ｐｅｄｉｃｕｌａｒｉｓ）中分离提取的苯丙素甙化合物（ｐｈｅｎｙｌｐｒｏｐａｎｏｉｄｇｌｙｃｏｓｉｄｅｓ，ＰＰＧ）对３种不同组织癌细胞生长的抑制活性。结果表明：６种ＰＰＧ的抗肿瘤活性强度与其化学结构密切相关；它们的抑癌活性强度顺序为：ｉｓｏｖｅｒｂａｓｃｏｓｉｄｅ，ｖｅｒｂａｓｃｏｓｉｄｅ，ｅｃｈｉｎａｃｏｓｉｄｅ，ｐｅｄｉｃｕｌａｒｉｏｓｉｄｅＡ＞ｃｉｓｔａｎｏｓｉｄｅＤ＞ｐｅｒｍｅｔｈｙｌｖｅｒｂａｓｃｏｓｉｄｅ；即分子中酚羟基越多，抗肿瘤活性愈强，当酚羟基完全被甲基化后，则对癌细胞生长无抑制作用。Using the MTT colorimetric assay,we studied antitumour effects of 6 phenyl-propanoid glycosides(PPG) from Pedicularis on three different tumour cell lines, The antitumoureffects of 6 PPG were related to their chemical structure,Their antitumour effects ranked asisoverbascoside, verbascoside,echinacoside, pedicularioside A >cistanoside D>permethyl verbas-coside.It was shown that the more number of phenolic hydroxyl groups,the stronger PPG’s anti-tumour effects.The phenolic hydroxyl groups were methoxylated,and PPG couldn’t inhibit thegrowth of tumour cells.

关 键 词：苯丙素甙 MTT 贴壁癌细胞 临床药理 

分 类 号：R979.1[医药卫生—药品]