石墨炉原子吸收法测定靶向制剂顺铂壳聚糖微球药物的含量  

Flameless atomic absorption spectrometric determination of cisplatincontent in cisplatin chitosan microspheres for targeting drug delivery

作　　者：王亚敏[1] 石庭森[1] 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《中国药学杂志》1995年第10期618-620,共3页Chinese Pharmaceutical Journal

摘　　要：为研究靶向制剂顺铂壳聚糖微球的制备工艺及理化性质，建立了石墨炉原子吸收分光光度法，用于壳聚糖微球顺铂含量及药物包封率的测定。铂标准曲线线性范围为０．１０～０．６０μｇ／ｍｌ，ｒ＝０．９９９６，平均回收率为１０２．４％，ＲＳＤ＝３．２９％，铂最低检测限为０．３０μｇ／ｍｌ。方法灵敏、准确、快速。To study the preparation procedure and characteristics of cisplatin chitosan micro-spheres for targeting drug delivery.We established flameless atomic absorption spectropho-tometry(FAAS)for determining the drug content and embedding rate of cisplatin chitosan micro-spheres.Microsphere sample was digested with 1:5 nitric acid.The standard curve of platinumwas linear in the range from 0.10 to 0.60 μg/ml(r=0.9996).Average recovery and RSD were102.4%and 3.29%respectively.The detection limit was 0.30 μg/ml.The method is sensible,ac-curate and rapid.

关 键 词：顺铂 壳聚糖 微球 分光光度法 药物含量测定 

分 类 号：R927.2[医药卫生—药学] R979.1