腹腔中毒性炎症对氨茶碱在大鼠小肠吸收的影响  

The Effects of Toxic Abdominal Inflammation on the Absorption of Aminophylline in Rat Intestines

作　　者：詹丽芬[1] 张玉芝[1] 郦幼鸣 王瑛珏[1] 陈子易[1] 刘文生 

机构地区：[1]中国医科大学基础医学院药理学教研室,中国医科大学基础医学院化学检测中心,辽阳市济慈医院

出　　处：《中国医科大学学报》1995年第6期569-571,共3页Journal of China Medical University

基　　金：卫生部归国人员启动基金课题

摘　　要：用四氯化碳使大鼠产生轻、中、重度中毒，在其小肠内建立恒温、恒速循环灌流的封闭装置，用一阶导数光谱法，定量地检测氨茶碱（Ａｍｉ）在大鼠小肠内吸收百分率的动态变化。结果在明：Ａｍｉ在正常大鼠消化管内，累积吸收百分率随时间的延长而增加。给药后１０和２０ｍｉｎ时吸收百分率明显增加，５０ｍｉｎ后吸收速率开始减慢。轻度中毒组用药后各时间吸收百分率有升高趋势。中度中毒组的各时间吸收百分率均低于对照组。严重中毒组吸收基本紊乱，失去规律。Mild, moderate and severe toxication were induced in rat abdominal cavity by ip carbon tetrachlo- ride.An apparatus for closed circulatory perfusion with constant temperature and speed was set up inthe intestine. The dynamic changes of absorption percentage(A%)of aminophylline(Ami)were deter-mined quantitatively in rat intestines by a first order derivative spectrophotometry.In normal rats,theaccumulative A%of Ami increased obviously, 10 and 20 min after perfusion, and the speed of absorp- tion began to decrease, 50 min after perfusion.The A%showed an increasing tendency in mild toxica-tion group in different period of time after perfusion.In moderate group,however, the A%was lowerthan that of the control.There was no regular absorption of Ami in severe group.

关 键 词：腹腔 中毒性炎症 小肠 氨茶碱 血液流变学 

分 类 号：R969.1[医药卫生—药理学]