基于三维打印技术的多药控释型载药人工骨生物学评价  

Biocompatibility of porous drug implant scaffolds based on 3D printing technology

作　　者：伍卫刚[1] 郑启新[1] 郭晓东[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院骨科,武汉430022

出　　处：《国际生物医学工程杂志》2009年第5期262-266,共6页International Journal of Biomedical Engineering

基　　金：国家高技术研究发展计划(863计划);教育部新世纪优秀人才支持计划

摘　　要：目的 评价三维打印技术制备的多药控释型载药人工骨的生物相容性.方法 利用三维打印技术制备多药控释型载药人工骨,并进行急性毒性试验、热源试验、皮肤刺激试验、溶血试验、微核试验和肌肉埋植试验等检测评价其生物相容性.结果 该多药控释型载药人工骨无全身急性毒性反应、无热源效应;皮肤刺激实验局部皮肤未见红斑、水肿反应;溶血率为0.29%,有良好的血液相容性;微核实验未见致突变现象.无细胞遗传毒性作用;肌肉埋植实验未见局部组织变性、坏死或排斥现象.结论 三维打印技术制备的多药控释型载药人工骨具有良好的生物相容性,符合医用生物材料的性能要求.Objective To evaluate the biocompatibility of porous drug implant scaffolds prepared by 3D printing technique. Methods Porous drug implant scaffolds were fabricated by 3D printing technique, and a series of tests were carried out to validate the biocompatibility, including acute systemic toxicity, hot source test, local irritation reaction, micronucleus test, muscle implant test and so on. Results The porous drug implant scaffolds showed no acute systemic toxicity, no pyrogenetic effect, no local erythema and edema in local irritation re-action, hemolysis rate of 0.29%, no cellular genetoxic. No local tissue denaturation, necrosis and exclusion were found in intramuscular implant test. Conclusion With good biocompatibility, the porous drug implant scaffold fabricated by 3D printing technique can meet the clinical requirement for biomaterial.

关 键 词：载药人工骨 三维打印 药物缓释系统 生物材料 组织工程 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]