布托啡诺预处理对非体外循环冠脉搭桥患者的心肌保护作用  

Preconditioning Effects of Butorphanol in Patients Undergoing Off-pump Coronary Artery bypass Graft Surgery

作　　者：徐忠东[1] 何伟雄[2] 金沐[3] 赵一凡[1] 夏淑轩[1] 何波[1] 杨涛[1] 曹德雄[1] 彭书峻[1] 李珏[1] 曹铭辉[1] 

机构地区：[1]中山大学附属第二医院麻醉科,510120 [2]中山大学附属肿瘤医院麻醉科 [3]中国医学科学院

出　　处：《岭南急诊医学杂志》2009年第5期375-376,355,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:观察布托啡诺预处理对非体外循环冠脉搭桥(OPCAB)患者的心肌保护作用。方法:选择24例行OPCAB的冠心病患者,随机分为布托啡诺预处理组(B组)和对照组(C组)。测定术前、术毕及术后1 h、6h、24 h、48 h血清cTnI水平。结果:各组内术后cTnI水平均明显增高(P<0.05),B组术后cTnI水平显著低于C组(P<0.05)。结论:布托啡诺预处理可降低OPCAB患者的cTnI水平,具心肌保护作用。Objective:To investigate the protective effect of butorphanol precondition against myocardial injury induced by OPCAB.Methods:24 patients undergoing OPCAB were randomly divided into control group (C-group, n=12) and butorphanol preconditioning group(B-group,n=12).Blood samples were obtained prior of the operation and at the 0 h,2 h,6 h,24 h,48 h after the end of the operation.The serum cTnI were determined.Results:The cTnI levels were significantly increased at the post-operative (0 h,2 h,6 h,24 h,48 h) compared with those before the operation(P<0.05).The cTnI levels of B-group were markedly lower than that in C-group after the operation(P< 0.05).Conclusion:Butorphanol precondition decreases the cTnI levels induced by OPCAB.

关 键 词：布托啡诺 预处理 非体外循环 冠脉搭桥 冠心病患者 心肌保护作用 cTnI OPCAB 术后 对照组 血清 随机 结果 方法 测定 

分 类 号：R614[医药卫生—麻醉学]