替罗非班治疗不同时间拔除动脉鞘管的急性冠状动脉综合征患者的安全性  

Evaluation on the safety of tirofiban in the treatment of acute coronary syndrome with immediate or delayed removal of artery sheath catheter

作　　者：荆素敏[1] 陈魁[1] 张艺 何飞[1] 姜正明[1] 张雅娉[1] 李蕾[1] 

机构地区：[1]郑州大学第一临床医学院心内科,450052

出　　处：《中国实用医刊》2010年第4期28-29,共3页Chinese Journal of Practical Medicine

摘　　要：目的 探讨不同时间拔除动脉鞘管对经皮冠状动脉介入治疗(PCI)术后血管并发症的影响,并探讨其与术后替罗非班应用的关系.方法 将150例急性冠状动脉综合征患者随机分为观察组(A组)73例和对照组(B组)77例,A组于PCI术后即刻拔除动脉鞘管,B组于PCI术后留置4 h后拔除动脉鞘.观察两组出血及拔管后压迫止血15 min后出血率.结果 对照组出血率较观察组明显增高,差异有统计学意义(P＜0.05).拔管后压迫止血15 min后,对照组出血率较观察组明显增高,差异有统计学意义(P＜0.05).结论 PCI术后即刻拔除动脉鞘管可以预防和减少血管并发症的发生,尤其应用替罗非班更适合早期拔管.Objective To investigate the effects of removing artery sheath catheter at different time points on blood vessel complications after PCI operation and evaluate whether tirofiban was associated with them. Methods The study was a parallel - group, randomized, controlled clinical trial, 150 patients with ACS who underwent selective PCI were randomly assigned to one of two treatment regimens , tirofiban was predominantly initiated in the catheter laboratory after the patients underwent selective PCI. In observation group of 73 patients, artery sheath catheter was removed immediate after PCI, while in control group of 77 patients, it was removed 4 h after PCI. The incidence of blood vessel complications in two groups were compared. Results There were more bleeding events happened in the control group compared with the observative group, and there was significantly differences between the two groups ( P＜0.05 ).Conclusions Immediate removal of the artery sheath catheter after PCI operation could prevent and reduce the occurrence of the blood vessel complications and is more suitable for patients treated with tirofiban.

关 键 词：经皮冠状动脉介入 拔管时间 血管并发症 替罗非班 

分 类 号：R541.4[医药卫生—心血管疾病]