胎盘、脐血及外周血造血干细胞免疫原性初步比较  

A pilot study on immunogenicity of mononuclear cell fromplacenta, cord blood and peripheral blood

作　　者：王飞[1] 刘玉峰[1] 张艳华[1] 毛彦娜[1] 

机构地区：[1]郑州大学第一附属医院儿科,450052

出　　处：《中国实用医刊》2010年第7期3-4,共2页Chinese Journal of Practical Medicine

摘　　要：目的 初步比较胎盘、脐血和外周血来源的造血干细胞的免疫原性.方法 应用单向混合淋巴细胞培养的方法将胎盘、脐血和外周血三种来源单个核细胞的增殖情况进行比较.结果 单向混合淋巴细胞培养中胎盘、脐血和外周血来源的细胞的增殖比较差异有统计学意义(P＜0.01).结论 胎盘较脐血和外周血来源的造血干细胞的免疫原性低,更适合用于异基因造血干细胞移植.Objective To compare phenotypic characteristics and immunog- genicity of hematopoietic stem cell(HSC)from placenta(PT), from cord blood(CB)and from peripheral blood(PB).Methods Comparing cell proliferation of PT, CB and PB using mixed - lymphocyte reactions(MLR).Results There was a difference in proliferation of PT, CB and PB(P ＜ 0.01).Conclusions Immunogenicity of HSC from PT are lower than that what from CB and PB.HSC of PT are more suitful for transplant of allogen hematopoietic stem cell.

关 键 词：胎盘 造血干细胞 免疫原性 混合淋巴细胞培养 

分 类 号：R4[医药卫生—临床医学]