转化生长因子-β1、基质金属蛋白酶组织抑制物-1、基质金属蛋白酶-1在绝经后盆腔器官脱垂患者阴道壁组织中表达的研究  

Study on the expression of transforming growth factor-β1 and tissue inhibitors of metalloproteinase-1 and matrix metalloproteinase-1 in paries anterior vaginase of postmenopausal female pelvic organ prolapse

作　　者：张丽丽[1] 张菊新[2] 刘广芝[2] 

机构地区：[1]郑州大学第一附属医院,450052 [2]河南省人民医院

出　　处：《中国实用医刊》2010年第12期21-23,共3页Chinese Journal of Practical Medicine

摘　　要：目的 探讨绝经后女性盆腔器官脱垂(POP)患者阴道壁组织中转化生长因子-β1(TGF-β1)、基质金属蛋白酶组织抑制物-1(TIMP1)和基质金属蛋白酶-1(MMP1)的表达与POP的关系.方法 选取30例绝经后盆腔器官脱垂患者(POP 组),并选择同期20例非卵巢功能性肿瘤和宫颈上皮内瘤变患者作为对照(对照组),采用免疫组化SP二步法检测患者阴道壁组织中TGF-β1、TIMP1、MMP1的表达,两组患者阴道壁组织中TGF-β1、TIMP1和MMP1含量的表达以阳性区平均积分光密度为标准.结果 TGF-β1和TIMP1在POP组的表达显著低于对照组,差异有统计学意义(P<0.01).MMP1在POP组的表达显著高于对照组,差异有统计学意义(P<0.01).结论 绝经后POP的发生可能与组织中表达的TGF-β1、TIMP1减少和MMP1增多有关.Objective To explore the relationship between transforming growth factor-β1 (TGF-β1) and tissue inhibitors of metalloproteinase-1 (TIMP1) and matrix metalloproteinase-1 (MMP1) with the occurrence of pelvic organ prolapse (POP) through analysis on TGF - β1 and TIMP1 and MMP1 in paries anterior vaginase of postmenopausal female pelvic organ prolapse. Methods The biopsy specimens in paries anterior vaginase were obtained from 50 subjects undergoing hysterectomia, tension-free vagina tape(TVT), burch procedures, who were assigned in the control, pelvic organ prolapse groups. TGF-β1 and TIMP1 and MMP1 in paries anterior vaginase was evaluated by immunohistochemical staining. Results TGF-β1 positive staining luminance and TIMP1 positive staining luminance were significantly lower in POP group than that in control group (P<0.01),MMP1 positive staining luminance was significantly higher in POP group than that in control group (P<0.01). Conclusions There is close relationship between degeneration of pelvic support construction and deficiency in TGF-β1 and TIMP1 declines in paries anterior vaginase of POP patient,and there is also close relationship between degeneration of pelvic support construction and accrescence in MMP1 of POP patient.

关 键 词：转化生长因子 基质金属蛋白酶组织抑制物 绝经后 女性盆腔器官脱垂 患者 阴道壁 织中表达 Study female TIMP1 relationship POP TGF positive control 统计学意义 对照组 平均积分光密度 宫颈上皮内瘤变 close 

分 类 号：R711[医药卫生—妇产科学]