不同剂量新斯的明拮抗国产顺式阿曲库铵肌肉松弛效应的观察  

Effeet of different doses of neostigmine on recovery from cisatracurium induced neuromuscular blockade

作　　者：薛文华[1] 赵杰[1] 

机构地区：[1]郑州大学第一附属医院药剂科,450052

出　　处：《中国实用医刊》2010年第12期28-29,共2页Chinese Journal of Practical Medicine

摘　　要：目的 观察不同剂量的新斯的明拮抗国产顺式阿曲库铵肌肉松弛的效应.方法 将36例ASA Ⅰ～Ⅱ级择期手术患者分为三组,每组12例,分别给予新斯的明20、35、50 μg/kg拮抗国产阿曲库铵肌肉松弛作用,并测定各组TOF0.70的时间.结果 新斯的明20 μg/kg产生的肌肉松弛恢复弱于35 μg/kg和50 μg/kg.而35 μg/kg和50 μg/kg所产生的肌肉松弛拮抗效果相似.结论 新斯的明剂量由20 μg/kg增加到50 μg/kg时,肌松拮抗加快,35 μg/kg为较理想的拮抗剂量.Objective To investigate the effect of different doses of neostigmine administration on recovery from cisatracrium induced neuromuscular blockade. Methods Thirty-six patients(ASA Ⅰ and Ⅱ) were divided into three groups(each twelve),and received neostigmine 20,35 and 50 μg/kg respectively. Results The speed of recovery from cisatracurium-induced neuromuscular blockade with neostigmine 20 μg/kg was lower as compared with 35 μg/kg and 50 μg/kg,but the difference was not significant between with neostigmine 35 μg/kg and 50 μg/kg. Conclusions Recovery from cisatracurium-induced neuromuscular blockade was accelerated when dose of neostigmine was increased from 20 μg/kg to 50 μg/kg,35 μg/kg is the optimal dose of neostigmine for reversal of cisatracufium-induced neuromuscular blockade.

关 键 词：新斯的明 顺式阿曲库铵 肌肉松弛 拮抗剂 

分 类 号：R614[医药卫生—麻醉学]