雷公藤多甙并卡托普利治疗小儿肾病型紫癜性肾炎疗效分析  

Efficacy of tripterygium wilfordii polyglycoside and captopril in the treatment of children with kidney-type purpura nephritis

作　　者：周嘉云[1] 张爱莉[1] 

机构地区：[1]山东省日照市人民医院儿科,276800

出　　处：《中国实用医刊》2010年第18期38-39,共2页Chinese Journal of Practical Medicine

摘　　要：目的 观察雷公藤多甙并卡托普利对小儿肾病型紫癜性肾炎的治疗效果.方法 将101例诊断为肾病型紫癜性肾炎的患儿随机分为治疗组58例(口服雷公藤多甙和卡托普利)和对照组43例(口服单剂强的松),观察药物对两组患儿水肿、高血压、血尿、蛋白尿的疗效,采用SPSS10.0软件进行统计学分析.结果 治疗组治愈51例(88%),有效7例(12%);对照组治愈26例(61%),有效17例(39%),两组治愈率比较差异有统计学意义(P<0.01),对水肿、血尿、高血压的疗效比较差异有统计学意义(P<0.05或P<0.01),对蛋白尿的疗效比较差异亦有统计学意义(P<0.01).结论 雷公藤多甙并卡托普利治疗小儿肾病型紫癜性肾炎疗效优于单剂强的松,值得临床应用.Objective To observed the efficacy of tripterygium wilfordii polyglycoside and captopril in the treatment of children with Henoch-Schonlein purpura nephritis kidney disease model. Methods One hundred and one children diagnosed with kidney-type purpura nephritis from May 1996 to June 2009 in our hospital, were respectively, randomly divided into treatment group (58 cases,oral tripterygium wilfordii polyglycoside and captopril) and the control group (43 patients, single-dose oral prednisone), observation of therapeutic effects of drugs in the two groups of children with edema, hypertension, hematuria, proteinuria efficacy, using SPSS10.0 software for statistical analysis. Results Fifty-one patients were cured (88%), effective in 7 patients (12%) in the treatment group, the control group cured 26 cases (61%), effective in 17 cases (39%), there was significant difference between the two groups (P<0.01). Pairs of edema, hematuria, hypertension were significantly different between the two groups(P<0.05 or P<0.01), and the efficacy of proteinuria was also significantly different (P<0.01). Conclusions Tripterygium wilfordii polyglycoside and captopril treatment of children with Henoch-Schonlein purpura nephritis kidney disease model is superior to single-dose prednisone, it is worth clinical application.

关 键 词：雷公藤多甙 卡托普利 强的松 肾病型紫癜性肾炎 

分 类 号：R726[医药卫生—儿科]