H-FABP检测在诊断早期急性心肌梗死中的价值  

Clinical evaluation of H-FABP in diagnosis of early AMI

作　　者：陈阵[1] 韩青[1] 李民[2] 

机构地区：[1]大连医科大学附属第一医院检验科 [2]解放军第210医院检验科,辽宁大连116021

出　　处：《临床军医杂志》2010年第5期816-818,共3页Clinical Journal of Medical Officers

摘　　要：目的 探讨血清心肌型脂肪酸结合蛋白(H-FABP)在早期急性心肌梗死(AMI) 诊断中的价值.方法 选择92例疑似急性心肌梗死的胸痛患者,采用快速检测试剂盒检测患者发病0～3 h、3～6 h 和6 h 后血清的H-FABP,并与心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)的检测结果进行比较,分析3种心肌标志物在诊断不同发病时间段AMI的敏感性和特异性.结果 H-FABP检测诊断AMI的敏感性在0～3 h(66.7%)和3～6 h(85.71%)时间段显著高于cTnI(16.67%、61.9%)和CK-MB(8.3%、66.7%);在诊断特异性上,H-FABP高于CK-MB,比cTnI低.结论 H-FABP对于诊断早期AMI具有较高的敏感性和良好的特异性,更适合于临床AMI的早期诊断.Objective To compare the diagnostic efficacy of a newly developed whole blood rapid panel test for heart-type fatty acid binding protein(H-FABP) with that of cardiac troponin I(cTnI) and creatine kinase isoenzyme MB(CK-MB).Methods To 92 patients suspicious of acute myocardial infarction(AMI),rapid panel test method was applied to detect the H-FABP according to certain time frame from onset to presentation,and cTnI and serum CK-MB activity were also determined.The sensitivity and specificity in diagnosis of early AMI were analyzed among H-FABP and cTnI and CK-MB.Results Final diagnosis was confirmed within 52 patients who had been suspicious of AMI.The relative sensitivities of these 3 markers were 66.7%,16.67% and 8.3% for AMI patients presented within 3 hours of onset of symptom,and 85.71%,61.9 % and 66.7% for those between 3 and 6 hours.While the relative specificities of these 3 markers were 91.67%,100% and 58.33% within 3 hours of onset,and 90.48%,95.24% and 76.19% for those between 3 and 6 hours.Conclusion H-FABP is more sensitive and specific in diagnosis of early AMI,which may has great potential as an excellent biochemical cardiac marker for diagnosis of AMI in the early phase.

关 键 词：H-FABP 快速检测试剂盒 诊断特异性 早期急性心肌梗死 价值 AMI diagnosis of 心肌型脂肪酸结合蛋白 敏感性和特异性 CK-MB 肌酸激酶同工酶 心肌肌钙蛋白 时间段 cTnI 心肌标志物 早期诊断 血清 胸痛患者 检测结果 检测诊断 

分 类 号：R82[医药卫生—临床医学]