左氧氟沙星致不良反应92例临床分析  

Clinical analysis on adverse reaction of levofloxacin on 92 cases

作　　者：李著[1] 王科兵[2] 张国庆[2] 冯习坤[2] 周焱[2] 

机构地区：[1]解放军第169医院普外科,湖南衡阳421002 [2]解放军第169医院药械科,湖南衡阳421002

出　　处：《临床军医杂志》2010年第6期1000-1001,共2页Clinical Journal of Medical Officers

摘　　要：目的探讨左氧氟沙星不良反应(adverse reaction,ADR)的临床特点。方法总结分析2008年1月—2010年4月我院门诊及住院患者中出现左氧氟沙星ADR的92例患者的相关因素、临床表现类型以及治疗和预后。结果本组年龄<60岁患者有35例(38.04%),年龄≥60岁患者有57例(61.96%);静脉用药发生患者83例(90.22%),口服用药者9例(9.78%);联合用药所致70例(76.09%),单独用药22例(23.91%)。本组变态反应35例(38.04%),发生率位居首位;其次消化系统反应20例(21.74%),全身性损害15例(16.30%)等。所有患者经调整滴速、停药或对症处理后症状均消失。结论左氧氟沙星ADR发生率日趋升高,临床医护人员应掌握其相关因素,合理用药。Objective To investigate the clinical feature of adverse reactions(ADR) of levofloxacin.Methods The datas of 92 cases with adverse reaction of levofloxacin in our hospital from January in 2008 to 2010 were analyzed to summarize the correlation factors of ADR,clinical manifestations,treatment and prognosis.Results There were 35 cases(38.04%)who were more than 60 years old and 57 cases(61.96%)who were less than 60 years old.There were 83 cases(90.22%) with adverse reaction by vein injection,9 cases(9.78%) with adverse reaction by mouth,70 cases(76.09%) were using combination therapy and 22 cases(23.91%) with single drug.The rate of cutaneous reactions was highest in the group and was 38.04% with 35 cases,and next were alimentary system with 20 cases(21.74%) general damage with 15 cases(16.30%) and so on The symptom of all cases were Vanished by treatment of adjusting dropping discontinuation and so on.Conclusion The rate of ADR about levofloxacin is in creasing quickly,so the clinic doctors and nurses must grasp the correlation factor of ADR,clinical manifestations and treatment to decrease the rate of ADR.

关 键 词：左氧氟沙星 不良反应 临床分析 住院患者 相关因素 发生率 治疗和预后 ADR 医护人员 系统反应 临床特点 联合用药 口服用药 静脉用药 合理用药 对症处理 单独用药 表现类型 变态反应 全身性 

分 类 号：R82[医药卫生—临床医学]