匹多莫德抑制频发性生殖器疱疹复发的临床观察  

Comparative study of intermitant and suppressive pidotimod therapy for recurrent genital herpes

作　　者：林大东[1] 

机构地区：[1]解放军第180医院皮肤科,福建泉州362000

出　　处：《临床军医杂志》2010年第6期1007-1009,共3页Clinical Journal of Medical Officers

摘　　要：目的观察在阿昔洛韦治疗基础上,匹多莫德间歇冲击疗法和长程抑制疗法对复发性生殖器疱疹复发频率及复发次数的抑制效果。方法 52例复发性生殖器疱疹患者按照半随机方式分配至间歇冲击治疗组(A组)和长程抑制治疗组(B组),两组均在生殖器疱疹复发就诊时开始给予常规阿昔洛韦基础治疗。A组27例,仅在疱疹复发时口服匹多莫德0.8 g,2次/d,连服10 d;B组25例,口服匹多莫德0.4 g,1次/d,连服6个月,治疗后观察随访12个月。结果在6个月治疗期间,A、B两组的复发率和平均复发次数无显著性差异,而在治疗后的12个月随访期间,B组的复发率及平均复发次数均明显低于A组。结论在阿昔洛韦治疗基础上,匹多莫德长程抑制疗法可有效降低复发性生殖器疱疹的复发率,减少复发次数,其疗效明显优于间歇冲击疗法。Objective To compare the preventing efficacy of intermitant and suppressive pidotimod therapy for genital herpes recurence.Methods 52 patients with recurrent genital herpes were firstly stratified according to their different frequency of recurence,and then hemi-randomly divided into two groups: the intermitant treatment group(group A) and the suppressive therapy group(group B).For all cases acylovir were given 0.4mg,twice daily consecutively for 6 months as basic therpy.For the 27 cases of group A,pidotimod was given 0.8,twice daily for 10 days only when the herpes relapsed.For the 25 cases of group B,pidotimod was given 0.4 once daily consecutively for 6 months.Both groups were followed-up for 12 months after the 6-month treatment.Results The average recurrent times per six months and the recurent rate of group A and group B were not significantly different during the 6-month therapy period.But the average recurrent times per six months and the recurent rate of group B was significantly lower than that of group A during the thereafter 12-month follow-up period.Conclusion The suppressive therapy of pidotimod has good effect for preventing genital herpes recurrence,and is significantly better than the intermitant treatment.

关 键 词：匹多莫德 抑制疗法 频发性 复发性生殖器疱疹 临床观察 recurrent genital herpes study 治疗基础 复发次数 间歇冲击疗法 阿昔洛韦 复发率 治疗组 无显著性差异 治疗期间 抑制效果 随访 疗效明显 口服 基础治疗 

分 类 号：R82[医药卫生—临床医学]