黄芪川芎小复方制剂联合甲基B12治疗糖尿病周围神经病变的临床研究  

Small compound preparation of Astragalus and Chuanxiong combined with methyl B12 in the treatment of diabetic peripheral neuropathy

作　　者：陆志明[1] 符佳[2] 李辉[2] 

机构地区：[1]成都市第一人民医院内分泌科,四川成都610016 [2]成都大学护理学院,四川成都610016

出　　处：《实用医院临床杂志》2010年第4期32-34,共3页Practical Journal of Clinical Medicine

摘　　要：目的观察黄芪川芎小复方制剂联合甲基B12治疗糖尿病周围神经病变(DPN)患者的临床疗效,并对其作用机制进行探讨。方法将60例DPN患者随机分为两组,每组各30例。两组基础治疗相同,试验组在基础治疗的基拙上给予黄芪川芎小复方制剂和甲基B12治疗,对照组接受单一甲基B12治疗,均连续用药12周,观察两组治疗前后神经肌电图、血浆高敏C反应蛋白(HsCRP)、丙二醛(MDA)、糖化血红蛋白及临床症状评分情况,并进行比较。结果两组总有效率、临床治愈率及显效率差异均有统计学意义(P<0.05);试验组神经肌电图、HsCRP及MDA治疗前后差异均有统计学意义(P<0.05),而对照组治疗前后差异无统计学意义(P>0.05)。结论黄芪川芎小复方制剂联合甲基B12治疗DPN疗效显著,其作用机制与抗炎、抗氧化有关。Objective To observe the clinical efficacy of small compound preparation of Astragalus and Chuanxiong combined with methyl B12 for patients with diabetic peripheral neuropathy(DPN),discuss the mechanism of action of the therapy.Methods Sixty patients with DPN were randomly divided into two groups,with 30 cases for each group.The experimental group was given the compound preparation and methyl B12 treatment on the basis of basic treatment,while control group was received a single methyl-B12 treatment for 12 weeks.Electromyography(EMG),plasma high-sensitivity C-reactive protein(HsCRP),malondialdehyde(MDA),glycated hemoglobin and clinical score were observed before and after treatment.Results There were significant differences between the two groups in total effective rate,clinical cure rate and effective rate.There were significant differences before and after treatment in EMG,HsCRP and MDA of experimental group,while there were no significant differences before and after treatment in those of control group.Conclusion Small compound preparation of Astragalus and Chuanxiong combined with methyl B12 has significant effect for patients with DPN.The mechanism of this therapy is closely associated with anti-inflammatory and anti-oxidation.

关 键 词：糖尿病 周围神经病变 黄芪 川芎 中西结合治疗 

分 类 号：R4[医药卫生—临床医学]