慢性阻塞性肺疾病患者系统性炎症与肺动脉高压的关系研究  

Systemic Inflammation in Patients with COPD and Pulmonary Hypertension

作　　者：何丹[1] 白淑荣[1] 

机构地区：[1]宁夏回族自治区人民医院,宁夏银川市750021

出　　处：《实用心脑肺血管病杂志》2010年第12期1768-1769,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)伴或不伴肺动脉高压与全身炎症反应的程度的关系。方法采用彩色多普勒超声心动图测定安静状态下收缩期肺动脉压(SPAP),并将46例COPD患者分为肺动脉高压组和无肺动脉高压组,测定患者血循环中的C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)以评估COPD全身炎症反应的程度。结果 46例患者,其中21例并发肺动脉高压,25例无肺动脉高压。肺动脉高压组患者血清CRP中位数17.5mg/L及TNF-α中位数7.4pg/ml,显著高于无肺动脉高压组患者的血清CRP中位数11.8mg/L及TNF-α中位数5.1pg/ml,差异均有统计学意义(P<0.05)。CRP对数转换值与SPAP呈正相关(r=0.637,P<0.05)。TNF-α对数转换值与SPAP无相关性。结论系统性炎症与COPD肺动脉高压形成有关。Objective To investigate the degree of systemic inflammation reflected by circulatory levels of C-reactive protein (CRP),tumor-necrosis factor (TNF)- α,in COPD patients with and without pulmonary hypertension.Mothods Pulmonary artery pressure (Ppa) levels were measured by echocardiography.SerumTNF-α levels were assessed by enzyme-linked immunosorbent assay,and serum CRP levels were measured by chemiluminescent immunoassay.lung function was assessed using body plethysmography.Results Pulmonary hypertension was present in 19 patients and was absent in 24 patients.In patients with pulmonary hypertension,serum CRP and TNF-α levels were significantly higher than in those patients without hypertension.Conclusion We conclude that increases in Ppa in patients with COPD are associated with higher serum levels of CRP and TNF-α.

关 键 词：慢性阻塞性肺疾病 疾病患者 系统性炎症 肺动脉高压 关系研究 Pulmonary Hypertension 中位数 全身炎症反应 TNF-α 彩色多普勒超声心动图 COPD SPAP CRP 统计学意义 坏死因子α 患者血清 换值 肺动脉压 反应蛋白 对数 

分 类 号：R54[医药卫生—心血管疾病]