多孔磷酸钙骨水泥与钛合金支架材料修复兔颅骨骨缺损的比较研究  

Comparison of Porous Calcium Acid Phosphate Cement and Titanium Alloy Scaffold in Repairing Skull Defect of Rabbits

作　　者：白峰 李国臣 刘建 王林 孟国林 桑宏勋 

机构地区：[1]Fourth Mil Med Univ, Xian 710032, Peoples R China

出　　处：《稀有金属材料与工程》2010年第11期1984-1988,共5页Rare Metal Materials and Engineering

基　　金：国家自然科学基金(30730034);国家教育部“十一五”科技项目(2006BAI02B03)

摘　　要：通过采用结构可控的多孔磷酸钙骨水泥(calcium acid phosphate cement,CPC)和钛合金支架材料修复兔颅骨骨缺损,比较了两种修复材料骨环境下的成骨性能。结果显示,与多孔钛合金材料相比,多孔CPC材料表现出了更好的成骨活性。CPC材料的新生骨量、成骨速率均高于钛合金材料。而且骨吸收重建过程也早于钛合金材料。同时,三维贯通的孔隙结构有利于骨组织的长入,能够在一定程度上克服钛合金材料的应力屏蔽缺陷,使植入体在早期获得良好的固位,从而使界面骨性结合得以顺利进行。The in vivo bone-regenerative capacity of porous calcium acid phosphate cement (CPC) and titanium alloy scaffold with controlled porous structure were investigated in rabbit calvarial defect models. The results show that the bone-regenerative capacity of porous CPC is much better than that of porous titanium alloy scaffold. Porous CPC exhibits more bone formation and higher mineralization appositional rate than porous titanium scaffold. Moreover, bone remolding of porous CPC is in earlier stage than that of porous titanium alloy scaffold. On the other hand, highly three-dimensional interconnected porous structure is beneficial for the growth of bone tissue. The mechanical properties of titanium alloy can be adapted to those of biological systems by applying a porous structure, which may enhance the integration process and improve implant fixation in earlier stage.

关 键 词：多孔 磷酸钙骨水泥 钛合金材料 支架材料 修复材料 颅骨骨缺损 比较研究 Titanium Alloy Acid 成骨性能 CPC 应力屏蔽 孔隙结构 结构可控 骨性结合 成骨活性 材料表现 植入体 骨组织 骨吸收 

分 类 号：R651.1[医药卫生—外科学]