固定剂量复合剂在流动人口与户籍人口结核病防治中的效果比较  

Compare of Fixed-dose Combinations Prevention and Treatment Effect in Tuberculosis Between Floating Population and Local Residents

作　　者：于梅[1] 董红军[1] 赵敏捷[1] 贺天峰[1] 顾永权 杜飞行[3] 殷立平[4] 

机构地区：[1]宁波市疾病预防控制中心,浙江宁波315000 [2]余姚市疾病预防控制中心,浙江余姚315400 [3]奉化市疾病预防控制中心,浙江奉化315500 [4]象山县疾病预防控制中心,浙江象山315700

出　　处：《中国初级卫生保健》2010年第11期44-46,共3页Chinese Primary Health Care

基　　金：宁波市科技局基金资助项目(200801C010027)

摘　　要：目的研究国产固定剂量复合剂(FDC)在流动人口和户籍人口中的结核病防治效果。方法将2008年3月1日—2009月3月1日发现的肺结核患者,按户口类型分为流动人口和户籍人口两组,在强化期和继续期分别使用HRZE(H75mg、R150mg、Z400mg及E275mg)和HR(H100mg、R150mg/H75mg、R150mg)进行治疗,观察两组治疗转归、痰菌阴转率及服药后血常规的变化和药物的可接受性等情况。结果在流动人口组和户籍人口组中,涂阳肺结核患者治愈率分别为79.17%和83.52%,第2、3、5和6个月末痰菌阴转率流动人口组分别为85.42%、93.75%、93.75%和95.83%,户籍人口组分别为90.11%、92.31%、97.80%和95.60%,差异无统计学意义(P>0.05)。不良反应率分别为9.47%和19.88%,差异有统计学意义(χ2=4.85,P=0.0277);在药物的可接受性上,流动人口组高于户籍人口组。在药物口感、药片数量和药片粘喉等问题上两组患者回答结果差异均无统计学意义。结论 FDC在流动人口与户籍人口中的治疗效果相同,但在流动人口中不良反应率低,更易被患者接受,应该进一步在流动人口中推广应用。OBJECTIVE To study the prevention and treatment effect of domestic fixed-dose combinations(FDC) in tuberculosis in floating population and local residents.METHODS Tuberculosis cases detected from march1,2008 to 2009 on march1 were divided into two groups,floating population group and local residents group.HRZE(R 150mg,H 75 mg,Z 400 mg,E 275 mg)and HR(H 100 mg,R 150 mg/H75mg,R 150 mg) were used to treat tuberculosis in intensive phase and continuation phase respectively.Many conditions were observed including treatment conversion,sputum negative conversion ratio,blood routine change after taking medicine,drug acceptability,and so on in the two groups.RESULTS In floating population group and local residents group,the cure rate of smear positive tuberculosis patients were 79.17% and 83.52%,the sputum negative conversion rates at the end of 2nd,3rd,5th and 6th month in the floating population group were 85.42%,93.75%,93.75% and 95.83% respectively,and the local residents group were 90.11%,92.31%,97.80% and 95.60% respectively.There was no significant difference between the two groups(P>0.05).The rate of adverse reactions in floating population group(9.47%)was significant lower than local residents group(19.88%).Drug acceptability of the floating population group was higher than that of the local residents group.The differences of the answers between the two groups patients in medicine taste,number of pills,pills’s viscosty,etc were insignificant.CONCLUSIONS The domestic FDC show similar treatment outcome in two groups,but it were lower adverse reactions rates and more acceptable in floating population group,whice should be further expanded in floating population group.

关 键 词：肺结核 固定剂量复合剂 预防与控制 流动人口 

分 类 号：R1[医药卫生—公共卫生与预防医学]