热射病的发病机制及防治策略的研究新进展  

Advance in Pathogenesis and Strategies of Protective and Therapeutic in Heat Stroke

作　　者：荣鹏[1] 孟建中[1] 陈宇[2] 

机构地区：[1]济南军区总医院,济南250031 [2]济南市妇幼保健院,济南250012

出　　处：《生物医学工程研究》2010年第4期287-292,共6页Journal Of Biomedical Engineering Research

基　　金：济南军区重点计划项目(CJN10L075)

摘　　要：热射病(heat stroke,HS)为致命性中暑,近期临床和实验证据进一步表明热射病的高死亡率可能是热细胞毒性、凝血紊乱和继发于肠道和其他器官损伤的全身炎症反应综合症(SIRS)的复杂相互作用所致。快速降温和多器官功能支持是其最有效的临床治疗方法,但是即使这样仍有许多患者会留下永久的神经系统损伤或者死亡,其死亡率高达10%～50%[4]。因此,综合分析HS患者的病理机制,探讨HS引起SIRS的易感因素,研究干预HS的适当时机,为推出新思路和救治新策略,降低HS死亡率是十分必要的。Heat stroke(HS) is a life-threatening heat illness.Recent clinical and experimental evidence suggests that a complex interplay between heat cytotoxicity,coagulation and the systemic inflammatory response syndrome(SIRS) that causes following damage to the gut and other organs is the primary determinant of morbidity and mortality of HS.Rapid cooling and support of multi-organ function are the most effective clinical treatments,but many patients experience permanent neurological impairments or death despite these efforts.The mortality rate is up to 10%～50%.Therefore,analysis of HS,new treatment to reduce the mortality rate are very necessary.In this paper the pathogenesis and prevention strategies are reviewed.The comprehensive analysis of pathogenesis of HS,predisposing factors of SIRS caused by HS,intervention moment of HS therapeusis are necessary for exploring novel therapeutic strategies.

关 键 词：热射病 发病机制 全身炎症反应综合症 防治策略 

分 类 号：R318[医药卫生—生物医学工程]