慢性乙肝携带者HBV DNA载量与肝组织炎症坏死程度相关性分析  

The Relation between Serum HBV DNA and the Grades of Liver Inflammation in Chronic Hepatitis B Virus Carriers

作　　者：陈仕祥[1] 何维新[1] 陈玺卿[1] 熊志远[1] 江军[1] 范平[1] 

机构地区：[1]解放军113医院感染科,浙江宁波315040

出　　处：《慢性病学杂志》2010年第12期1599-1600,共2页Chronic Pathematology Journal

摘　　要：目的分析慢性乙型肝炎病毒携带者血清HBV DNA定量与肝组织病理炎症相关性,以判定是否以1×105拷贝/ml作为进行肝组织活检的标准。方法选取慢性乙型肝炎病毒携带者244例,行肝穿刺病理检查、肝功能、HBV DNA、乙肝标志物,依据血清HBV DNA将患者分为高载量(≥105)和低载量(<105)两组,同时依据肝脏炎症程度分级分<G2、≥G2两组。结果 244例患者中炎症分级G≥2者48例(19.7%);HBV DNA高载量组和低载量组肝组织炎症分级无统计学意义(P>0.05),<G2分级、≥G2分级两组中HBV DNA载量比较亦无统计学意义(P>0.05)。结论多数慢性乙型肝炎病毒携带者有轻度炎症,炎症分级G≥2者占19.7%;肝脏炎症程度与血清HBVDNA无相关性,1×105拷贝/ml不能作为是否进行肝组织活检的标准。Objective To study the relationship between the qualification of HBV DNA and the liver inflammation in chronic hepatitis B virus (HBV)arriers.Methods 244 chronic HBV carriers were examined with Liver biopsy、liver function、HBV-DNA level and serological markers of B-hepatitis.examination.Groups were divided based on the grades of liver inflammation and serum HBV DNA levels.Results All of the 244 cases,48(19.7%)had inflammation stage G≥ 2,No significant differences were observed in the inflammation between HBV DNA high/low groups.Conclusion Most chronic HBV carriers had mild inflammatory histological changes in their livers.the grades of liver inflammation were not correlated with HBV DNA in sera.

关 键 词：肝炎病毒 乙型/遗传学 DNA 病毒 肝/病理学 人类 

分 类 号：R512.62[医药卫生—内科学]