七丹胶囊对CCl_4致小鼠急性肝损伤的保护作用  

Pharmacodynamics study of Qidan capsules on CCl_4-inducted acute liver injury in mice

作　　者：高明菊[1,2] 王强[3] 蒋洁云[3] 崔秀明[1,2] 

机构地区：[1]文山三七研究院,云南文山663000 [2]云南省三七农业工程实验室,云南文山663000 [3]中国药科大学,江苏南京210009

出　　处：《华西药学杂志》2010年第6期688-690,共3页West China Journal of Pharmaceutical Sciences

基　　金：云南省新药研发专项(2003XY11)

摘　　要：目的采用体外细胞培养和体内试验,探讨三七总皂苷与丹参总酚酸不同配比的药效作用,以确定二者的最佳配伍比例。方法研究三七总皂苷与丹参总酚酸不同配比对体外细胞的培养和对CCl4诱导的小鼠急性肝损伤的影响。结果三七总皂苷和丹参总酚酸对CCl4诱导的小鼠急性肝损伤有明显的保护作用,二者配伍后作用增强,以三七总皂苷-丹参总酚酸为5:1时的保护作用最强。结论两者均有保肝、抑制成纤维细胞增殖的作用,配伍后作用增强,毒性降低。OBJECTIVE To explore the efficacy of different ratio between the PNS and salvia acid.METHODS In in vitro cell culture experiments,the CCl4-induced acute liver injury in mice was applied.RESULTS PNS and salvia acid on CCl4-induced acute liver injury in mice had significantly protective effect.The protective effect was enhanced with the cornbination of PNS and solution total acid.When the PNS and salvia total acid ratio was 5:1,the protective effect was the best.CONCLUSION PNS and salvia acid have liver prote...

关 键 词：三七总皂苷 丹参总酚酸 七丹胶囊 急性肝损伤 保肝 成纤维细胞 

分 类 号：R285.5[医药卫生—中药学]