血清同型半胱氨酸与冠心病的相关性研究  

Correlation between Serum Homocysteine and Coronary Heart Disease

作　　者：熊杰[1] 白生华[2] 徐万清[1] 古宇[1] 龚杨彬[1] 刘华伟[3] 

机构地区：[1]四川成都军区总医院检验科,四川省成都市610083 [2]四川成都医学院第一附属医院,四川省成都市610500 [3]四川成都市第三人民医院临床医学检验部,四川省成都市610031

出　　处：《中国分子心脏病学杂志》2010年第6期326-327,共2页Molecular Cardiology of China

摘　　要：目的探讨冠心病患者血清同型半胱氨酸(homocysteine,Hcy)水平变化的临床意义。方法检测106例冠心病患者和50例健康对照组的血清Hcy的水平。结果冠心病患者血清Hcy水平较健康对照组明显升高(P<0.01);稳定型心绞痛、不稳定型心绞痛及急性心肌梗死三组Hcy比较水平依次升高,差异有统计学意义(P<0.05)。Hcy水平随着冠状动脉病变支数的增加依次升高,有显著性差异(P<0.05)。结论血清Hcy水平变化与冠状动脉病变的严重程度相关,是冠状动脉病变程度的重要危险因素之一。Objective To investigate the relation between serum homocysteine(homocysteine,Hcy)levels and the severity of coronary heart disease.Methods The serum Hcy level was measured in 106 patients with coronary heart disease and 50 healthy controls.Results Levels of the serum Hcy was significantly higher in patients with coronary heart disease than that in healthy controls(P<0.01).Hcy levels had an significantly increase trend in patients with stable angina、unstable angina,and acute myocardial infarction(P<0.05).Hcy levels also significantly increased with the severity of coronary vessel disease(P<0.05).Conclusion Elevated Hcy levels were significantly associated with the risk of coronary heart disease and could serve as a marker of the severity of coronary heart disease.

关 键 词：同型半胱氨酸 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]