复方胆通片质量标准的研究  

Study on Quality Criteria for Compound Dantong Tablet

作　　者：李学涛[1] 田景振[2] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]山东中医药大学中药学院,山东济南510006

出　　处：《食品与药品》2010年第11期407-411,共5页Food and Drug

摘　　要：目的建立复方胆通片的质量标准。方法采用薄层色谱法鉴别方中的大黄、溪黄草与胆通;用高效液相色谱法测定羟甲香豆素和齐墩果酸的含量。结果薄层色谱法能明显检测出大黄、溪黄草、胆通,薄层图谱斑点清晰,阴性对照无干扰;羟甲香豆素进样量在4.92～49.2μg范围内呈良好线性关系(r=0.999 7),平均加样回收率为98.79%;齐墩果酸进样量在0.3～3.0μg范围内呈良好线性关系(r=0.999 3),平均加样回收率为99.90%。结论所建标准可用于复方胆通片的质量控制。Objective To establish the quality criteria for Compound Dantong Tablet.Methods Rhubarb,serrate rabdosia herb and hitrechol in the formula were identif ied by TLC and the contents of hymecromone and oleanolic acid was determined by HPLC.Results Rhubarb,serrate rabdosia herb and hitrechol could be detected by TLC.The spots in the TLC were clear and identif ied without the interference of negative control.The 1inear range of hymecromone was 4.92～49.2 μg(r = 0.999 7).The average recovery was 98.79 %.The 1inear...

关 键 词：复方胆通片 薄层色谱法 高效液相色谱法 质量标准 

分 类 号：R286[医药卫生—中药学]