OHSS患者VEGF、slL-2R及NO的联合检测及临床研究  

Combined Determination and Clinical Research of VEGF,slL-2R and NO OHSS in Patients

作　　者：肖淑辉[1] 季海生[1] 任兴斌[1] 

机构地区：[1]山东省临沂市人民医院,临沂276003

出　　处：《医学检验与临床》2006年第1期56-58,共3页Medical Laboratory Science and Clinics

基　　金：临沂市科技发展计划项目;编号:0434053。

摘　　要：Objective To study the roles Of VEGF,No and lymphcyte slL-2R in theonsert of ovarian hyper-stimulation syndromeOHSS) with combined determination of these factors in the liquor folliculi and plasma of OHSS patients.Methods The liquoufolliculi,blood sample of the day Of ovum-takingS1),and blood sample of the seventh dayafter ovum-takingS7) of 12 cases of moderate to severe OHSS patientsOHSS group) and 26 cases of patients without OHSScontrol group)were collected in the period of ⅣF—ET And the levels of VEGF,NO and lymphcyte slL-2R were determined to observe their regular rule of change.Results The levels Of VEGFand lymphcyte slL-2R in the liquor follichli and S1 of the OHSS group were not significantly different from those of the control groupP>0.05),but the level of NO was significantly different that of the control,groupP>0.01).The levels Of VEGF,NO and lymphcyte sIL-2R in S7 were significantly different from those of the control groupP<0.01).Conclusion VEGF may take part in the onset of OHSS.The increase of the expression of lymphcyte sIL-2R indicates the participation of immune factors in the process of onset.As excessive NO in OHSS patients exerts pathologic action,its cytotoxic effect stimulates immunocytes to realease inflammatory cell factor,which further increase the expression of VEGF and worsens the patient’s,condition.It is simple to monitor the level of NO and lymphcyte sIL-2R in blood samples.Objective To study the roles Of VEGF,No and lymphcyte slL-2R in theonsert of ovarian hyper-stimulation syndromeOHSS) with combined determination of these factors in the liquor folliculi and plasma of OHSS patients.Methods The liquoufolliculi,blood sample of the day Of ovum-takingS_1),and blood sample of the seventh dayafter ovum-takingS_7) of 12 cases of moderate to severe OHSS patientsOHSS group) and 26 cases of patients without OHSScontrol group)were collected in the period of ⅣF—ET And the levels of VEGF,NO and lymphcyte slL-2R were determined to observe their regular rule of change.Results The levels Of VEGFand lymphcyte slL-2R in the liquor follichli and S_1 of the OHSS group were not significantly different from those of the control groupP>0.05),but the level of NO was significantly different that of the control,groupP>0.01).The levels Of VEGF,NO and lymphcyte sIL-2R in S_7 were significantly different from those of the control groupP<0.01).Conclusion VEGF may take part in the onset of OHSS.The increase of the expression of lymphcyte sIL-2R indicates the participation of immune factors in the process of onset.As excessive NO in OHSS patients exerts pathologic action,its cytotoxic effect stimulates immunocytes to realease inflammatory cell factor,which further increase the expression of VEGF and worsens the patient's,condition.It is simple to monitor the level of NO and lymphcyte sIL-2R in blood samples.

关 键 词：患者 联合检测 临床研究 血管内皮细胞生长因子 可溶性白细胞介素 发病机理 卵巢过度刺激 肝肾功能衰竭 发生率 控制超排卵 不同时间段 一氧化氮 体外受精 胚胎移植 临床意义 中重度 胸腹水 胃肠道 卵泡液 诊治 

分 类 号：R446.6[医药卫生—诊断学] R446.1[医药卫生—临床医学]