肾小管标记物测定在慢性肾功能不全病人中的结果探讨  

The significance of renal tubular markers in chronic renal failure patients

作　　者：解冰[1] 江利萍[1] 

机构地区：[1]江苏省镇江市中西医结合肾脏病研究所,江苏212028

出　　处：《医学检验与临床》2006年第6期15-16,18,共3页Medical Laboratory Science and Clinics

摘　　要：目的通过测定肾小管标记物THP、RBP、α1-MG、β2-MG,NAG、IL-6、ET-1及肾小管功能的项目(CH2O),判断肾功能不全病人的肾小管-间质损伤及炎症程度。方法应用放射免疫法测定IL-6、ET-1、THP、RBP、α1-MG、2β-MG,用ELISA沾测定RBP,用比色法测定NAG,用物理学方法测定CH2O。结果ET-l、RBP、2β-MG、CH2O的结果均是根据CRF病情分型逐渐上升,THP、IL-6是逐渐下降而1α-MG、NAG在CRF-Ⅱ以后均比CRF-I高但CRF-Ⅱ、Ⅲ、Ⅳ之间有高有低没有明显差异(p>0.05)。结论通过监测多种肾小管标记物及细胞因子可以对肾功能不全病人的肾间质损伤及炎性状态起到很好的诊断,对治疗有一定的指导作用。Objective To explore through test the marker of renal tubular( THP,RBP,α_1-MG,β_2-MG,NAG,ET-1),tubular function projeat(CH_2O) and the inflammation medium(IL-6),judge renal tubular to suffer injury and the inflammation the degree in chronic renal failure.Methods Determines THP,RBP,α_1-MG,β_2-MG,ET-I,IL-6 with RIA;determines RBP with ELISA;determines NAG with the colormethod;determines CH_2O with the physics method.Results ET-1,RBP,β_2-MG,CH_2O results are based on sub-type CRF gradually risen,THP,IL-6 is gradually declining and α_1-MG,NAG in CRF-Ⅱ later than CRF-I high but CRF-II,CRF-III,CRF-IV between high low no obviousdifterences(p>0.05).Conclusion Many kind of renal tubular and the cell factor may renal-tubular the nature damage and the inflammation character condition play the very gooo diagnosis.Through the monitor to the kidney function in chnoric renal failure patient,has the certain instruction role to thetreatment.

关 键 词：肾小管功能 标记物 放射免疫法测定 慢性肾功能不全 病人 肾间质损伤 物理学方法 比色法测定 炎症程度 细胞因子 状态 治疗 诊断 应用 监测 分型 

分 类 号：R692.5[医药卫生—泌尿科学]