肠杆菌科产超广谱β-内酰胺菌株的调查分析  

A Survey and Analysis Based on Extended Spectrum β-Lactmases Producing Enterobacteriaceae Bacteria

作　　者：张文[1] 高庆平[1] 

机构地区：[1]山东淄博市中心医院,淄博255036

出　　处：《医学检验与临床》2006年第6期26-27,共2页Medical Laboratory Science and Clinics

摘　　要：目的监测产超广谱β-内酰胺酶(ESBLs)菌株的耐药情况,指导临床医生合理应用抗生素,控制院内感染。方法采用纸片协同法检测ESBLs菌株,并对82株产ESBLs菌株进行分析。结果产ESBLs菌株主要为大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌。研究发现,产ESBLs菌株与长期住院和应用广谱抗生素及健康等级差、住ICU病房等有明显关系,并且具有多重耐药性。结论产ESBLs的肠杆菌科细菌引起的感染日益增多,实验室及临床医生应注重ESBLs的监测和报告,合理应用抗生素,控制ESBLs菌株的流行。Objective To monitor the condition of drug reaistance of the ESBLs and to dinect the chinic touse antibiotic correctly and decrease nosocomiai infections.Methods Eighty-two strains of ESBLs-producing isolates were detected with double disk diffusion test Results.The ESBLs-producing strains were mainly E.coli,K.Pnemnoniae and E.cloacae.lt is also found that The ESBLs-producing strains is significantly correlated with long term clinical treaatmatory antibiotictherapy,poor health and intensive care unil(ICU) patients,and the ESBLs-preducing strains showed verymultidrug reaiamace agaimt antibiotic.Conclusions There has been inccreasingly occurred nosocomialinfection of ESBLs-producing entero bacteriaceae bacteria,it ia impotant to surveillance and control theESBLs-producers for clinician laboratory and it should be cautious to use antibiotics to control theepidemic of the ESBLs-producing strains.

关 键 词：肠杆菌科细菌 超广谱β 内酰胺酶 菌株 广谱抗生素 临床医生 应用 肺炎克雷伯菌 纸片协同法 阴沟肠杆菌 多重耐药性 大肠埃希菌 院内感染 控制 健康等级 监测 实验室 住院 检测 方法 

分 类 号：R446.5[医药卫生—诊断学]