β地中海贫血复合血红蛋白E18例基因分析和补肾生血中药治疗临床研究  

To study the clinical significance of chinese traditional medicine(CTM) in treating 18 cases of β-thalassemia combined with hemoglobin E(β-thal/HbE) confirmed by Gene Analysis

作　　者：黄欣秋[1] 张新华[2] 王琳[1] 吴志奎[3] 柴立民[3] 杜华[1] 王荣新[2] 

机构地区：[1]广西壮族自治区人民医院,南宁530021 [2]解放军303医院,南宁530021 [3]中国中医研究院广安门医院,北京100053

出　　处：《内科》2006年第1期15-16,共2页Internal Medicine

基　　金：广西自然科学基金项目(0385004)

摘　　要：目的研究茁-地中海贫血复合血红蛋白E的基因突变型及用中药益髓生血颗粒治疗前后效果的临床分析。方法临床诊断为茁-地贫血/HbE患者18例,男性10例,女性8例,年龄6～35岁,平均15.6岁。采用反向斑点杂交技术进行基因检测。应用益髓生血颗粒治疗每次10g,每日3次,3个月为1疗程。结果18例病人茁珠蛋白基因突变类型共有四种,经治疗后症状改善,Hb、RBC、Ret及HbF值均有增高,治疗前后P<0.05。结论益髓生血灵颗粒治疗-地中海贫血复合血红蛋白E有较好疗效,值得临床上推广应用。Objective To study mutant types of β-thal/HbE and clinical significance of CTM(Yisui shengxue granule) in treating β-thal/HbE.Methods We treated 18 cases of β-thal/HbE(Male 10,Female 8).Ages were 6～35 years(mean age 15.6 years).Genes were analyzed by reverse dot blot(RDB).Yisuishengxue granule were taken orally 10g per time,thrice per day,each course of treatment was 3 months.Results Four mutant types were confirmed.After one course of the treatment the symptoms of 18 cases improved,Hb,RBC,Ret,HbF increased significantly in total 18 cases(P<0.05).Conclusion CTM(Yisuishengxue granule) can be used in treating β-thal/HbE,and is worth further popularizing.

关 键 词：Β地中海贫血 复合 血红蛋白 基因分析 补肾生血 中药治疗 临床研究 chinese traditional medicine clinical significance study 益髓生血颗粒 反向斑点杂交技术 基因突变类型 益髓生血灵 基因突变型 症状改善 推广应用 临床诊断 临床分析 基因检测 

分 类 号：R259[医药卫生—中西医结合]